Abstract

An environmentally friendly method for the efficient synthesis of biologically active 1,4-dihydropyridine derivatives has been performed. The reaction was carried out under solvent-free conditions using chitosan magnetic nanocomposite of Ch-Rhomboclase as an efficient heterogeneous recyclable catalyst. The chitosan magnetic nanocomposite was synthesized through a comfortable and reasonably priced method. It was specified by FT-IR, XRD, EDS, SEM, TEM, VSM, and TGA analyses. Mild reaction conditions, absence of toxic solvent, low catalyst loading, high speed and efficiency, magnetically removable catalyst, and reusability of catalyst are the most important advantages of this method for the synthesis of Hantzsch 1,4-dihydropyridines.

Graphic abstract

中文翻译：

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壳聚糖磁性纳米复合材料：一种在无溶剂条件下绿色合成Hantzsch 1,4-二氢吡啶的磁性可重复使用纳米催化剂

摘要

已经进行了有效合成生物活性的1，4-二氢吡啶衍生物的环境友好方法。该反应在无溶剂条件下使用Ch-Rhomboclase的壳聚糖磁性纳米复合材料作为有效的多相可循环催化剂进行。壳聚糖磁性纳米复合材料是通过一种舒适且价格合理的方法合成的。它是通过FT-IR，XRD，EDS，SEM，TEM，VSM和TGA分析指定的。温和的反应条件，无毒溶剂的存在，催化剂用量低，速度和效率高，可磁性除去的催化剂以及催化剂的可重复使用性是合成Hantzsch 1,4-二氢吡啶的方法的最重要优点。

图形摘要