Abstract

In the presents work synthesis and characterization of new heterocyclic derivatives containing pyrazolo[3,4-d]pyrimidine linkage with 1,4-disubstituted-1,2,3-triazoles via methylene-oxy group. The selected synthesized compounds were tested for their in-vitro anticancer activity against various cancer cell lines. Synthesis of compounds was done under ultrasonic-assisted Huisgen 1,3-dipolar cycloaddition reaction with good yields. Some of the newly synthesized compounds demonstrated good to moderate anticancer activity, most of compounds shows activity against renal cancer cell lines.

中文翻译：

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1,2,3-三唑系吡唑并[3,4-d]嘧啶-4-醇的超声辅助合成及其抗癌活性

摘要

在本工作中，合成和表征了新的含吡唑并[3,4- d ]嘧啶键与经由亚甲基-氧基取代的1,4-二取代-1,2,3-三唑的杂环衍生物。测试了选定的合成化合物对各种癌细胞系的体外抗癌活性。化合物的合成是在超声辅助的Huisgen 1,3-偶极环加成反应下完成的，收率很高。一些新合成的化合物显示出良好至中等的抗癌活性，大多数化合物显示出对肾癌细胞系的活性。