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Ultrasonic-Assisted Synthesis of Pyrazolo[3,4-d]pyrimidin-4-ol Tethered with 1,2,3-Triazoles and Their Anticancer Activity

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Abstract

In the presents work synthesis and characterization of new heterocyclic derivatives containing pyrazolo[3,4-d]pyrimidine linkage with 1,4-disubstituted-1,2,3-triazoles via methylene-oxy group. The selected synthesized compounds were tested for their in-vitro anticancer activity against various cancer cell lines. Synthesis of compounds was done under ultrasonic-assisted Huisgen 1,3-dipolar cycloaddition reaction with good yields. Some of the newly synthesized compounds demonstrated good to moderate anticancer activity, most of compounds shows activity against renal cancer cell lines.

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ACKNOWLEDGMENTS

Authors are thankful to the Department of Chemistry, Saurashtra University, Rajkot for the providing laboratory facilities and spectral analysis. The authors are also thankful to the National Cancer Institute [50], a part of the National Institute of Health (NIH), for the providing anticancer screening of compounds.

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Authors and Affiliations

  1. Department of Chemistry, Saurashtra University, Rajkot-360005, Gujrat, India

    Prakash L. Kalavadiya, Vimal H. Kapupara, Dinesh G. Gojiya, Tejal D. Bhatt, Sanjay D. Hadiyal & Dr. Hitendra S. Joshi

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  1. Prakash L. Kalavadiya
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  2. Vimal H. Kapupara
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Correspondence to Dr. Hitendra S. Joshi.

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Prakash L. Kalavadiya, Kapupara, V.H., Gojiya, D.G. et al. Ultrasonic-Assisted Synthesis of Pyrazolo[3,4-d]pyrimidin-4-ol Tethered with 1,2,3-Triazoles and Their Anticancer Activity. Russ J Bioorg Chem 46, 803–813 (2020). https://doi.org/10.1134/S1068162020050106

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