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Biologically Active Pyridazines and Pyridazinone Derivatives: A Scaffold for the Highly Functionalized Compounds
Russian Journal of Bioorganic Chemistry ( IF 1.1 ) Pub Date : 2020-10-23 , DOI: 10.1134/s1068162020050155 Mohd Imran , Mohammad Asif
中文翻译:
具有生物活性的哒嗪和哒嗪酮衍生物:一种高度官能化化合物的支架
更新日期:2020-10-30
Russian Journal of Bioorganic Chemistry ( IF 1.1 ) Pub Date : 2020-10-23 , DOI: 10.1134/s1068162020050155 Mohd Imran , Mohammad Asif
Abstract
Pyridazine and pyridazinone are heterocycles that contain two adjacent nitrogen atoms and shown wide range of pharmacological activities such as antimicrobial, antidepressant anti-hypertensive, anticancer, antiplatelet, antiulcer, herbicidal, antifeedant and various other anticipated biological activities. Pyridazine ring are present in some commercially available drugs and agrochemicals. Pyridazine based systems have been shown to have numerous practical applications.
中文翻译:
具有生物活性的哒嗪和哒嗪酮衍生物:一种高度官能化化合物的支架
摘要
哒嗪和哒嗪酮是含有两个相邻氮原子的杂环,它们具有广泛的药理活性,例如抗微生物剂,抗抑郁药,抗高血压药,抗癌药,抗血小板药,抗溃疡药,除草剂,抗饲料药和各种其他预期的生物学活性。哒嗪环存在于一些市售药物和农用化学品中。基于哒嗪的系统已显示具有许多实际应用。