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Calcium signaling modulates the dynamics of cilia and flagella
European Biophysics Journal ( IF 2.2 ) Pub Date : 2020-10-26 , DOI: 10.1007/s00249-020-01471-8
M V Satarić 1 , S Zdravković 2 , T Nemeš 3 , B M Satarić 3
Affiliation  

To adapt to changing environments cells must signal and signaling requires messengers whose concentration varies with time in space. We here consider the messenger role of calcium ions implicated in regulation of the wave-like bending dynamics of cilia and flagella. The emphasis is on microtubules as polyelectrolytes serving as transmission lines for the flow of Ca2+ signals in the axoneme. This signaling is superimposed with a geometric clutch mechanism for the regulation of flagella bending dynamics and our modeling produces results in agreement with experimental data.



中文翻译:

钙信号调节纤毛和鞭毛的动态

为了适应不断变化的环境,细胞必须发出信号,而发出信号需要信使,其浓度随空间时间而变化。我们在这里考虑了钙离子的信使作用,涉及纤毛和鞭毛的波浪状弯曲动力学的调节。重点是作为聚合电解质的微管用作轴丝中 Ca 2+信号流的传输线。该信号与用于调节鞭毛弯曲动力学的几何离合器机制叠加,我们的建模产生的结果与实验数据一致。

更新日期:2020-10-30
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