Lung cancer is continuously the leading cause of cancer related death. Noninvasive exhaled breath condensate (EBC) detection using portable devices may pave a new avenue for monitoring conditions of the high-risk population of lung cancer, thereby increasing the 5-year survival rate. Here, a portable system is proposed for on-line detection of carcinoembryonic antigen (CEA) in EBC. This miniaturized system employs an aptameric Love-wave sensor to provide a detection with advantages of low cost, operational simplicity and high sensitivity. In addition, the aptasensor can be used in label-free and real-time monitoring. Integrating with measurement circuits and iOS APP, the system realizes online transmission and processing of signals which reflect the CEA concentration. Artificial samples have been detected, and experimental results demonstrate that the present system is sensitive (limit of detection = 1 ng/ml) and accurate (relative accuracy = 0.995). Applying in detection of clinical EBC, the relative error is as low as 0.305% and the result can be used to distinguish lung cancer patients from healthy subjects. Therefore, this portable system offers a potential solution for noninvasive detection of lung cancer in its early stage.

肺癌一直是癌症相关死亡的主要原因。使用便携式设备进行无创呼出气冷凝物（EBC）检测可能为监测肺癌高危人群的状况开辟新途径，从而提高5年生存率。在此，提出了一种便携式系统用于在线检测 EBC 中的癌胚抗原（CEA）。该小型化系统采用适配乐夫波传感器提供检测，具有成本低、操作简单和灵敏度高的优点。此外，适体传感器还可用于无标记、实时监测。系统结合测量电路和iOS APP，实现反映CEA浓度信号的在线传输和处理。对人工样品进行了检测，实验结果表明该系统灵敏（检测限= 1 ng/ml）且准确（相对准确度= 0.995）。应用于临床EBC检测，相对误差低至0.305%，结果可用于区分肺癌患者与健康受试者。因此，这种便携式系统为肺癌早期无创检测提供了潜在的解决方案。