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Love wave based portable sensing system for on-line detection of carcinoembryonic antigen in exhaled breath condensate

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Abstract

Lung cancer is continuously the leading cause of cancer related death. Noninvasive exhaled breath condensate (EBC) detection using portable devices may pave a new avenue for monitoring conditions of the high-risk population of lung cancer, thereby increasing the 5-year survival rate. Here, a portable system is proposed for on-line detection of carcinoembryonic antigen (CEA) in EBC. This miniaturized system employs an aptameric Love-wave sensor to provide a detection with advantages of low cost, operational simplicity and high sensitivity. In addition, the aptasensor can be used in label-free and real-time monitoring. Integrating with measurement circuits and iOS APP, the system realizes online transmission and processing of signals which reflect the CEA concentration. Artificial samples have been detected, and experimental results demonstrate that the present system is sensitive (limit of detection = 1 ng/ml) and accurate (relative accuracy = 0.995). Applying in detection of clinical EBC, the relative error is as low as 0.305% and the result can be used to distinguish lung cancer patients from healthy subjects. Therefore, this portable system offers a potential solution for noninvasive detection of lung cancer in its early stage.

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Acknowledgments

My baby was born in January 2019. For most of time, I need to take care of her on my own. Since I was pregnant, I’ve had trouble in sleeping and this problem was getting worse after my baby was born. The stress of working and lack of sleeping have driven me to postpartum depression. Thanks to my husband for encouraging me all the time and volunteering to take care of our baby after work. My parents also gave me lots of help. It is the love of my family that help me get through the depression and get back to work. Herein, I want to thank the support from family.

Funding

This work was supported by Natural Science Foundation of Hunan Province No. 2020JJ5624 to YC.Z..

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Authors and Affiliations

  1. School of Electronic Information and Electrical Engineering, Changsha University, Changsha, 410003, China

    Yingchang Zou, Yuan Zhou & Ying Chen

  2. Biosensor National Special Lab, Key Lab for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, Zhejiang University, Hangzhou, 310027, China

    Xi Zhang

  3. Zhejiang Sir Run Run Shaw Hospital, Department of Medicine, Zhejiang University, Hangzhou, 310027, China

    Chunxue Ran

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  1. Yingchang Zou
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  2. Yuan Zhou
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  3. Ying Chen
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  4. Xi Zhang
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  5. Chunxue Ran
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Correspondence to Yingchang Zou.

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Zou, Y., Zhou, Y., Chen, Y. et al. Love wave based portable sensing system for on-line detection of carcinoembryonic antigen in exhaled breath condensate. Biomed Microdevices 22, 78 (2020). https://doi.org/10.1007/s10544-020-00533-0

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