The disruption of apoptotic cell death process is closely associated with the etiology of various diseases, including cancer. Permanent viral infections can cause different types of cancers. Oncogenic viruses manipulate both external and internal apoptosis pathways, and inhibit the activity of proapoptotic proteins and signaling pathways, which facilitates carcinogenesis. Ineffective immune surveillance or immune response suppression can induce uncontrolled virus propagation and host cell proliferation. In this review, we discuss current data that provide insights into mechanisms of apoptotic death suppression by viruses and their role in oncogenesis.

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病毒感染：细胞凋亡和致癌因子的负调节因子

凋亡细胞死亡过程的中断与包括癌症在内的各种疾病的病因学密切相关。永久性病毒感染可导致不同类型的癌症。致癌病毒操纵外部和内部凋亡通路，并抑制促凋亡蛋白和信号通路的活性，从而促进致癌作用。无效的免疫监视或免疫反应抑制会导致不受控制的病毒繁殖和宿主细胞增殖。在这篇综述中，我们讨论了当前数据，这些数据提供了对病毒抑制细胞凋亡的机制及其在肿瘤发生中的作用的见解。