Herein, we report a novel therapy for prostate cancer based on systemically delivered magnetic hyperthermia. Conventional magnetic hyperthermia is a form of thermal therapy where magnetic nanoparticles delivered to cancer sites via intratumoral administration produce heat in the presence of an alternating magnetic field (AMF). To employ this therapy for prostate cancer tumors that are challenging to inject intratumorally, we designed novel nanoclusters with enhanced heating efficiency that reach prostate cancer tumors after systemic administration and generate desirable intratumoral temperatures upon exposure to an AMF. Our nanoclusters are based on hydrophobic iron oxide nanoparticles doped with zinc and manganese. To overcome the challenges associated with the poor water solubility of the synthesized nanoparticles, the solvent evaporation approach was employed to encapsulate and cluster them within the hydrophobic core of PEG-PCL (methoxy poly(ethylene glycol)-b-poly(ε-caprolactone))-based polymeric nanoparticles. Animal studies demonstrated that, following intravenous injection into mice bearing prostate cancer grafts, the nanoclusters efficiently accumulated in cancer tumors within several hours and increased the intratumoral temperature above 42 °C upon exposure to an AMF. Finally, the systemically delivered magnetic hyperthermia significantly inhibited prostate cancer growth and did not exhibit any signs of toxicity.

中文翻译：

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系统性地提供磁疗治疗前列腺癌

本文中，我们报告了一种基于全身递送磁热疗的前列腺癌新疗法。常规的磁热疗是一种热疗法，其中通过肿瘤内给药传递到癌症部位的磁性纳米粒子会在交变磁场（AMF）存在的情况下产生热量。为了将这种疗法用于挑战性地在肿瘤内注射的前列腺癌肿瘤，我们设计了具有增强的加热效率的新型纳米簇，其在全身给药后到达前列腺癌肿瘤并在暴露于AMF时产生理想的瘤内温度。我们的纳米簇基于掺杂有锌和锰的疏水性氧化铁纳米颗粒。为了克服与合成纳米颗粒水溶性差有关的挑战，b -聚（ε -己内酯）） -基聚合物的纳米颗粒。动物研究表明，在向带有前列腺癌移植物的小鼠静脉内注射后，纳米团簇在数小时内有效地积聚在癌症肿瘤中，并在暴露于AMF后将瘤内温度提高至42°C以上。最后，全身递送的磁热疗显着抑制了前列腺癌的生长，并且没有表现出任何毒性迹象。