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Pregnancy and Delivery in Patients With Repaired Congenital Heart Disease ― A Retrospective Japanese Multicenter Study ―
Circulation Journal ( IF 3.1 ) Pub Date : 2020-10-14 , DOI: 10.1253/circj.cj-19-1150
Shinichi Takatsuki 1 , Yoshiyuki Furutani 2 , Kei Inai 2 , Tohru Kobayashi 3 , Ryo Inuzuka 4 , Tomomi Uyeda 5 , Mitsuhiro Kamisago 6 , Jun Muneuchi 7 , Masahide Kaneko 8 , Yasushi Misaki 8 , Hiroshi Ono 8 , Hitoshi Kato 8 , Eriko Shimada 2 , Tokuko Shinohara 2 , Kenji Waki 9 , Kenji Suda 10 , Yasunobu Hayabuchi 11 , Hirotaka Ohki 12 , Reina Ishizaki 13 , Jun Maeda 12, 13 , Hiroyuki Yamagishi 13
Affiliation  

Background:Although advances in cardiac surgery have led to an increased number of survivors with congenital heart disease (CHD), epidemiological data regarding the pregnancies and deliveries of patients with repaired CHD are scarce.

Methods and Results:In this study, we retrospectively reviewed the clinical outcomes of pregnancies and deliveries of women with repaired CHD. Overall, 131 women with repaired CHD were enrolled and there were 269 gestations. All patients were classified as New York Heart Association (NYHA) Class I or II. The prevalence of cesarean sections was higher in patients with (CyCHD) than without (AcyCHD) a past history of cyanosis (51% vs. 19%, respectively; P<0.01). There were 228 offspring from 269 gestations and the most prevalent neonatal complication was premature birth (10%), which was more frequent in the CyCHD than AcyCHD group (15.7% vs. 5.6%, respectively; P<0.01). Five maternal cardiac complications during delivery were observed only in the CyCHD group (8%); these were classified as NYHA Class II and none was fatal.

Conclusions:Delivery was successful in most women with repaired CHD who were classified as NYHA Class I or II, although some with CyCHD and NYHA Class II required more attention. Cesarean sections were more common in the CyCHD than AcyCHD group, and CyCHD may be a potential risk for preterm deliveries.



中文翻译:

先天性心脏病修复患者的妊娠和分娩——一项回顾性日本多中心研究——

背景:尽管心脏手术的进步导致先天性心脏病 (CHD) 幸存者数量增加,但关于先天性心脏病修复患者的妊娠和分娩的流行病学数据很少。

方法和结果:在这项研究中,我们回顾性地审查了先天性心脏病修复妇女的妊娠和分娩的临床结果。总共招募了 131 名患有先天性心脏病修复的女性,共有 269 次妊娠。所有患者均被归类为纽约心脏协会 (NYHA) I 级或 II 级。既往有紫绀病史的(CyCHD)患者剖宫产率高于无(AcyCHD)患者(分别为51%和19%;P<0.01)。有 228 名后代来自 269 次妊娠,最常见的新生儿并发症是早产 (10%),CyCHD 组比 AcyCHD 组更常见(分别为 15.7% 和 5.6%;P<0.01)。仅在 CyCHD 组 (8%) 中观察到 5 种产妇在分娩期间的心脏并发症;这些被归类为 NYHA II 级,没有一个是致命的。

结论:大多数被归类为 NYHA I 级或 II 级的修复性 CHD 女性的分娩是成功的,尽管一些患有 CyCHD 和 NYHA II 级的女性需要更多的关注。剖宫产在 CyCHD 中比 AcyCHD 组更常见,并且 CyCHD 可能是早产的潜在风险。

更新日期:2020-10-28
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