Pregnancy and Delivery in Patients With Repaired Congenital Heart Disease　― A Retrospective Japanese Multicenter Study ―

Shinichi Takatsuki; Yoshiyuki Furutani; Kei Inai; Tohru Kobayashi; Ryo Inuzuka; Tomomi Uyeda; Mitsuhiro Kamisago; Jun Muneuchi; Masahide Kaneko; Yasushi Misaki; Hiroshi Ono; Hitoshi Kato; Eriko Shimada; Tokuko Shinohara; Kenji Waki; Kenji Suda; Yasunobu Hayabuchi; Hirotaka Ohki; Reina Ishizaki; Jun Maeda; Hiroyuki Yamagishi

doi:10.1253/circj.CJ-19-1150

This article has now been updated. Please use the final version.

Pregnancy and Delivery in Patients With Repaired Congenital Heart Disease　― A Retrospective Japanese Multicenter Study ―

Shinichi Takatsuki, Yoshiyuki Furutani, Kei Inai, Tohru Kobayashi, Ryo Inuzuka, Tomomi Uyeda, Mitsuhiro Kamisago, Jun Muneuchi, Masahide Kaneko, Yasushi Misaki, Hiroshi Ono, Hitoshi Kato, Eriko Shimada, Tokuko Shinohara, Kenji Waki, Kenji Suda, Yasunobu Hayabuchi, Hirotaka Ohki, Reina Ishizaki, Jun Maeda, Hiroyuki Yamagishi

Author information

Shinichi Takatsuki
Department of Pediatrics, Toho University Omori Medical Center [Japan]
Yoshiyuki Furutani
Pediatric Cardiology and Adult Congenital Cardiology, Tokyo Women’s Medical University [Japan]
Kei Inai
Pediatric Cardiology and Adult Congenital Cardiology, Tokyo Women’s Medical University [Japan]
Tohru Kobayashi
Department of Development Strategy, Center for Clinical Research and Development, National Center for Child Health and Development [Japan]
Ryo Inuzuka
Department of Pediatrics, The University of Tokyo Hospital [Japan]
Tomomi Uyeda
Department of Pediatric Cardiology, Sakakibara Heart Institute [Japan]
Mitsuhiro Kamisago
Department of Pediatrics, Nippon Medical School Tama Nagayama Hospital [Japan]
Jun Muneuchi
Department of Pediatric Cardiology, Japan Health Care Community Organization Kyushu Hospital [Japan]
Masahide Kaneko
Department of Pediatric Cardiology, National Center for Child Health and Development [Japan]
Yasushi Misaki
Department of Pediatric Cardiology, National Center for Child Health and Development [Japan]
Hiroshi Ono
Department of Pediatric Cardiology, National Center for Child Health and Development [Japan]
Hitoshi Kato
Department of Pediatric Cardiology, National Center for Child Health and Development [Japan]
Eriko Shimada
Pediatric Cardiology and Adult Congenital Cardiology, Tokyo Women’s Medical University [Japan]
Tokuko Shinohara
Pediatric Cardiology and Adult Congenital Cardiology, Tokyo Women’s Medical University [Japan]
Kenji Waki
Department of Pediatrics, Kurashiki Central Hospital [Japan]
Kenji Suda
Department of Pediatrics, Kurume University Hospital [Japan]
Yasunobu Hayabuchi
Department of Pediatrics, Tokushima University Hospital [Japan]
Hirotaka Ohki
Department of Cardiology, Tokyo Metropolitan Children’s Medical Center [Japan]
Reina Ishizaki
Department of Pediatrics, Keio University School of Medicine [Japan]
Jun Maeda
Department of Cardiology, Tokyo Metropolitan Children’s Medical Center [Japan]
Department of Pediatrics, Keio University School of Medicine [Japan]
Hiroyuki Yamagishi
Department of Pediatrics, Keio University School of Medicine [Japan]

Keywords: Adult congenital heart disease, Cesarean section, Premature, Tetralogy of Fallot

JOURNAL OPEN ACCESS FULL-TEXT HTML Advance online publication

Article ID: CJ-19-1150

DOI https://doi.org/10.1253/circj.CJ-19-1150

The final version of this article is now available: Vol. 84 (2020), No. 12 pp. 2270-2274

Details

Abstract

Background:Although advances in cardiac surgery have led to an increased number of survivors with congenital heart disease (CHD), epidemiological data regarding the pregnancies and deliveries of patients with repaired CHD are scarce.

Methods and Results:In this study, we retrospectively reviewed the clinical outcomes of pregnancies and deliveries of women with repaired CHD. Overall, 131 women with repaired CHD were enrolled and there were 269 gestations. All patients were classified as New York Heart Association (NYHA) Class I or II. The prevalence of cesarean sections was higher in patients with (CyCHD) than without (AcyCHD) a past history of cyanosis (51% vs. 19%, respectively; P<0.01). There were 228 offspring from 269 gestations and the most prevalent neonatal complication was premature birth (10%), which was more frequent in the CyCHD than AcyCHD group (15.7% vs. 5.6%, respectively; P<0.01). Five maternal cardiac complications during delivery were observed only in the CyCHD group (8%); these were classified as NYHA Class II and none was fatal.

Conclusions:Delivery was successful in most women with repaired CHD who were classified as NYHA Class I or II, although some with CyCHD and NYHA Class II required more attention. Cesarean sections were more common in the CyCHD than AcyCHD group, and CyCHD may be a potential risk for preterm deliveries.

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