Toxoplasmosis is a zoonotic protozoal disease caused by Toxoplasma gondii, an intracellular opportunistic protozoan parasite that can infect any warm-blooded vertebrate cell. In this study, zirconium, and iron-based metal-organic framework was prepared according to the solvothermal method. New nanocomposite (Curcumin@MOFs) was prepared by reacting curcumin with amino-functionalized metal-organic frameworks (Fe-MOF and UiO-66-NH₂). Besides characterizations of the composite by powder X-ray diffraction and scanning electron microscope, nano-Curcumin@MOFs was used as a new novel structure as atrial for treatment of chronic toxoplasmosis. Results showed a reduced number of brain cysts, high levels of serum Toxo IgG, and normal histo-morphology with preserved parenchymal, and stromal tissues in rats groups treated with curcumin and Curcumin@MOFs nanocomposite.

弓形虫病是一种由弓形虫引起的人畜共患原生动物疾病，弓形虫是一种细胞内机会性原生动物寄生虫，可以感染任何温血脊椎动物细胞。在这项研究中，锆和铁基金属有机骨架是根据溶剂热法制备的。通过姜黄素与氨基功能化金属有机骨架（Fe-MOF 和 UiO-66-NH ₂）。除了通过粉末 X 射线衍射和扫描电子显微镜对复合材料进行表征外，纳米姜黄素@MOFs 还被用作治疗慢性弓形虫病的新型心房。结果表明，姜黄素和姜黄素@MOFs 纳米复合材料治疗组大鼠脑囊肿数量减少，血清 Toxo IgG 水平升高，组织形态正常，实质和间质组织得以保留。