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Curcumin@metal organic frameworks nano-composite for treatment of chronic toxoplasmosis

  • Biomaterials Synthesis and Characterization
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Abstract

Toxoplasmosis is a zoonotic protozoal disease caused by Toxoplasma gondii, an intracellular opportunistic protozoan parasite that can infect any warm-blooded vertebrate cell. In this study, zirconium, and iron-based metal-organic framework was prepared according to the solvothermal method. New nanocomposite (Curcumin@MOFs) was prepared by reacting curcumin with amino-functionalized metal-organic frameworks (Fe-MOF and UiO-66-NH2). Besides characterizations of the composite by powder X-ray diffraction and scanning electron microscope, nano-Curcumin@MOFs was used as a new novel structure as atrial for treatment of chronic toxoplasmosis. Results showed a reduced number of brain cysts, high levels of serum Toxo IgG, and normal histo-morphology with preserved parenchymal, and stromal tissues in rats groups treated with curcumin and Curcumin@MOFs nanocomposite.

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Authors and Affiliations

  1. Zoology Department, Faculty of Science, Benha University, Benha, Egypt

    Aziza A. M. El-Shafey & Moshira M. E. Seliem

  2. Medical Parasitology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

    Mohammed. H. A. Hegab, Nahed E. Mostafa & Hanem A. Abdel-Maksoud

  3. Zoonotic Diseases Department, National Research Centre, 33 Bohouth str. Dokki, Giza, Egypt

    Ashraf M. A. Barakat

  4. Applied Organic Chemistry Department, Chemical Industries Research Division, National Research Centre, 33 Bohouth str. Dokki, Giza, Egypt

    Reda M. Abdelhameed

Authors
  1. Aziza A. M. El-Shafey
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  2. Mohammed. H. A. Hegab
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  3. Moshira M. E. Seliem
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Correspondence to Reda M. Abdelhameed.

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El-Shafey, A.A.M., Hegab, M.H.A., Seliem, M.M.E. et al. Curcumin@metal organic frameworks nano-composite for treatment of chronic toxoplasmosis. J Mater Sci: Mater Med 31, 90 (2020). https://doi.org/10.1007/s10856-020-06429-y

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  • DOI: https://doi.org/10.1007/s10856-020-06429-y

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