A ferrocene-linked metal-covalent organic polymer as a peroxidase-enzyme mimic for dual channel detection of hydrogen peroxide,Analyst

当前位置： X-MOL 学术 › Analyst › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

A ferrocene-linked metal-covalent organic polymer as a peroxidase-enzyme mimic for dual channel detection of hydrogen peroxide
Analyst ( IF 3.6 ) Pub Date : 2020-10-20 , DOI: 10.1039/d0an01837f
Qiong Hu _{1,

2,

3,

4,

5} , Yishan Fang _{6,

7,

8,

9,

10} , Xiongtao Yu _{1,

2,

3,

4,

5} , Jianzhi Huang _{1,

2,

3,

4,

5} , Lishi Wang _{1,

2,

3,

4,

5}

Affiliation

A novel ferrocene-linked metal-covalent organic polymer (MCOP-NFC) was synthesized through the Claisen–Schmidt condensation reaction of 1,1′-diacetyl ferrocene and tris(4-formylphenyl)amine. MCOP-NFC acts as a highly efficient artificial enzyme for mimicking peroxidase, and shows good stability in harsh chemical environments including strong bases and acids, and boiling water. Based on the peroxidase-like activity of MCOP-NFC, a highly sensitive dual channel detection method for hydrogen peroxide was developed. For the colorimetric detection strategy, the limit of detection (LOD) reached 2.1 μM, while the limit of detection was found to be as low as 0.08 μM based on the electrochemical detection channel. This study offers a new strategy for the development of an enzyme mimetic on the basis of the covalent assembly of nanostructures, and the proposed electrochemical–colorimetric sensor for H₂O₂ detection has great potential for applications in biology and biomedicine.

中文翻译：

二茂铁连接的金属共价有机聚合物作为过氧化物酶模拟物用于双通道检测过氧化氢

通过1,1'-二乙酰基二茂铁与三（4-甲酰基苯基）胺的Claisen-Schmidt缩合反应合成了一种新型的二茂铁连接的金属共价有机聚合物（MCOP-NFC）。MCOP-NFC是模仿过氧化物酶的高效人工酶，在苛刻的化学环境（包括强碱和强酸和沸水）中显示出良好的稳定性。基于MCOP-NFC的过氧化物酶样活性，开发了一种用于双氧水的高灵敏度双通道检测方法。对于比色检测策略，基于电化学检测通道，检测限（LOD）达到2.1μM，而检测限低至0.08μM。这项研究为基于纳米结构共价组装的酶模拟物的开发提供了新的策略，₂ O₂检测在生物学和生物医学中具有巨大的应用潜力。

更新日期：2020-11-12

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11