A ferrocene-linked metal-covalent organic polymer as a peroxidase-enzyme mimic for dual channel detection of hydrogen peroxide

Qiong Hu; Yishan Fang; Xiongtao Yu; Jianzhi Huang; Lishi Wang

doi:10.1039/D0AN01837F

A ferrocene-linked metal-covalent organic polymer as a peroxidase-enzyme mimic for dual channel detection of hydrogen peroxide†

Qiong Hu,^a Yishan Fang,

^b Xiongtao Yu,^a Jianzhi Huang^a and Lishi Wang

*^a

Author affiliations

* Corresponding authors

^a Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641, China
E-mail: wanglsh@scut.edu.cn

^b State Key Laboratory of Biobased Material and Green Papermaking, School of Food Science and Engineering, Qilu University of Technology, Shandong Academy of Sciences, Jinan 250353, China

Abstract

A novel ferrocene-linked metal-covalent organic polymer (MCOP-NFC) was synthesized through the Claisen–Schmidt condensation reaction of 1,1′-diacetyl ferrocene and tris(4-formylphenyl)amine. MCOP-NFC acts as a highly efficient artificial enzyme for mimicking peroxidase, and shows good stability in harsh chemical environments including strong bases and acids, and boiling water. Based on the peroxidase-like activity of MCOP-NFC, a highly sensitive dual channel detection method for hydrogen peroxide was developed. For the colorimetric detection strategy, the limit of detection (LOD) reached 2.1 μM, while the limit of detection was found to be as low as 0.08 μM based on the electrochemical detection channel. This study offers a new strategy for the development of an enzyme mimetic on the basis of the covalent assembly of nanostructures, and the proposed electrochemical–colorimetric sensor for H₂O₂ detection has great potential for applications in biology and biomedicine.

Supplementary files

Article information

DOI: https://doi.org/10.1039/D0AN01837F
Article type: Paper
Submitted: 13 Sep 2020
Accepted: 20 Oct 2020
First published: 20 Oct 2020

Download Citation

Analyst, 2021,146, 487-494

Permissions

Request permissions

A ferrocene-linked metal-covalent organic polymer as a peroxidase-enzyme mimic for dual channel detection of hydrogen peroxide

Q. Hu, Y. Fang, X. Yu, J. Huang and L. Wang, Analyst, 2021, 146, 487 DOI: 10.1039/D0AN01837F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Analyst

A ferrocene-linked metal-covalent organic polymer as a peroxidase-enzyme mimic for dual channel detection of hydrogen peroxide†

Abstract

Supplementary files

Article information

Download Citation

Permissions

A ferrocene-linked metal-covalent organic polymer as a peroxidase-enzyme mimic for dual channel detection of hydrogen peroxide

Social activity

Search articles by author

Spotlight

Advertisements