Abstract—

It is commonly known that the antiviral activity of the TRIM5α protein, the intracellular retrovirus restriction factor, underlies the resistance of the Old World monkeys to HIV-1. This fact suggests that TRIM5α can potentially be used to cure HIV-1 infection in humans. The present review considers the mechanisms of HIV-1 replication inhibition by the TRIM5α protein and the prospects for using it in gene therapy of HIV infection.

中文翻译：

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逆转录病毒限制因子TRIM5α：作用机制和用于HIV感染基因治疗的前景。

摘要-

众所周知，细胞内逆转录病毒限制因子TRIM5α蛋白的抗病毒活性是旧猴对HIV-1的抗性的基础。这一事实表明，TRIM5α可以潜在地用于治愈人类的HIV-1感染。本文综述了TRIM5α蛋白抑制HIV-1复制的机制，并将其用于HIV感染的基因治疗。