Abstract Adipose tissue is an important organ in our body, participating not only in energy metabolism but also immune regulation. It is broadly classified as white (WAT) and brown (BAT) adipose tissues. WAT is highly heterogeneous, composed of adipocytes, various immune, progenitor and stem cells, as well as the stromal vascular populations. The expansion and inflammation of WAT are hallmarks of obesity and play a causal role in the development of metabolic and cardiovascular diseases. The primary event triggering the inflammatory expansion of WAT remains unclear. The present review focuses on the role of adipocyte progenitors (APS), which give rise to specialized adipocytes, in obesity-associated WAT expansion, inflammation and fibrosis.

中文翻译：

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白色脂肪组织的扩张和炎症——关注脂肪细胞祖细胞

摘要 脂肪组织是人体重要的器官，不仅参与能量代谢，还参与免疫调节。它大致分为白色 (WAT) 和棕色 (BAT) 脂肪组织。WAT 是高度异质的，由脂肪细胞、各种免疫细胞、祖细胞和干细胞以及基质血管群组成。WAT 的扩张和炎症是肥胖的标志，在代谢和心血管疾病的发展中起着因果作用。引发 WAT 炎症扩张的主要事件仍不清楚。本综述重点关注脂肪细胞祖细胞 (APS) 在肥胖相关 WAT 扩张、炎症和纤维化中的作用，APS 会产生特化的脂肪细胞。