Abstract
Adipose tissue is an important organ in our body, participating not only in energy metabolism but also immune regulation. It is broadly classified as white (WAT) and brown (BAT) adipose tissues. WAT is highly heterogeneous, composed of adipocytes, various immune, progenitor and stem cells, as well as the stromal vascular populations. The expansion and inflammation of WAT are hallmarks of obesity and play a causal role in the development of metabolic and cardiovascular diseases. The primary event triggering the inflammatory expansion of WAT remains unclear. The present review focuses on the role of adipocyte progenitors (APS), which give rise to specialized adipocytes, in obesity-associated WAT expansion, inflammation and fibrosis.
Funding source: Hong Kong Health and Medical Research Fund
Award Identifier / Grant number: 04151796
Funding source: Research Grant Council grants from the General Research Fund
Award Identifier / Grant number: 17153016
Funding source: Collaborative Research Fund
Award Identifier / Grant number: C7037-17W
Funding source: Area of Excellence scheme
Award Identifier / Grant number: AoE/M/707-18
Acknowledgements
This work was supported by the grants from Hong Kong Health and Medical Research Fund (04151796), Research Grant Council grants from the General Research Fund (17153016), Collaborative Research Fund (C7037-17W) and the Area of Excellence scheme (AoE/M/707-18).
Author contribution: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: This work was supported by the grants from Hong Kong Health and Medical Research Fund (04151796), Research Grant Council grants from the General Research Fund (17153016), Collaborative Research Fund (C7037-17W) and the Area of Excellence scheme (AoE/M/707-18).
Conflict of interest statement: The authors declare no conflicts of interest regarding this article.
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