Multimodal imaging in the second near-infrared window (NIR-II) guided cancer therapy is a highly precise and efficient cancer theranostic strategy. However, it is still a challenge to develop activated NIR-II optical imaging and therapy agents. In this study, we develop a pH-responsive hybrid plasmonic-fluorescent vesicle by self-assembly of amphiphilic plasmonic nanogapped gold nanorod (AuNNR) and fluorescent down-conversion nanoparticles (DCNP) (AuNNR-DCNP Ve), showing remarkable and activated NIR-II fluorescence (FL)/NIR-II photoacoustic (PA) imaging performances. The hybrid vesicle also exhibited superior loading capacity of doxorubicin as a superior drug carrier and efficient radiosensitizer for X-ray-induced radiotherapy. Interestingly, the accumulated hybrid AuNNR-DCNP Ve in the tumor resulted in a recovery of NIR-II FL imaging signal and a variation in NIR-II PA imaging signal. Dual activated NIR-II PA and FL imaging of the hybrid vesicle could trace drug release and precisely guided cancer radiotherapy to ultimately reduce the side effects to healthy tissue.

在第二个近红外窗口（NIR-II）指导的癌症治疗中进行多模式成像是一种高度精确且有效的癌症治疗方法。然而，开发活化的NIR-II光学成像和治疗剂仍然是一个挑战。在这项研究中，我们通过两亲性等离激元纳米间隙金纳米棒（AuNNR）和荧光下转换纳米粒子（DCNP）（AuNNR-DCNP Ve）的自组装，开发了一种pH响应型等离激元荧光囊泡，显示出显着的活化NIR II荧光（FL）/ NIR-II光声（PA）成像性能。杂种囊泡还表现出优异的阿霉素负载能力，可作为一种优良的药物载体和有效的放射增敏剂，用于X射线诱导的放射治疗。有趣的是 肿瘤中积累的杂交AuNNR-DCNP Ve导致NIR-II FL成像信号的恢复和NIR-II PA成像信号的变化。混合囊泡的双重激活NIR-II PA和FL成像可以追踪药物释放并精确指导癌症放疗，从而最终减少对健康组织的副作用。