The study of novel mechanisms of action of vanadium compounds is critical to elucidating the role and importance of these kinds of compounds as antitumor and antimetastatic agents. This work deals with in silico and in vitro studies of one clioquinol oxidovanadium(IV) complex [VO(clioquinol)₂], VO(CQ)₂, and its regulation of FAK. In particular, we focus on elucidating the relationship of the FAK inhibition, MMP activity and antimetastatic effects of the complex in human bone cancer cells.

中文翻译：

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VO-氯碘羟喹对 2D 和 3D 人骨肉瘤癌细胞中 FAK/MMP 信号轴抑制的计算机模拟和体外分析

钒化合物新作用机制的研究对于阐明这类化合物作为抗肿瘤和抗转移剂的作用和重要性至关重要。这项工作涉及一种氯碘羟喹氧化钒 ( IV ) 复合物 [VO(clioquinol) ₂ ]、VO(CQ) ₂及其对 FAK 的调节的计算机模拟和体外研究。特别是，我们专注于阐明 FAK 抑制、MMP 活性和复合物在人骨癌细胞中的抗转移作用之间的关系。