In silico and in vitro analysis of FAK/MMP signaling axis inhibition by VO-clioquinol in 2D and 3D human osteosarcoma cancer cells

Lucia M. Balsa; Patricia Quispe; Enrique J. Baran; Martin J. Lavecchia; Ignacio E. León

doi:10.1039/D0MT00176G

In silico and in vitro analysis of FAK/MMP signaling axis inhibition by VO-clioquinol in 2D and 3D human osteosarcoma cancer cells†

Lucia M. Balsa,^a Patricia Quispe,^a Enrique J. Baran,^a Martin J. Lavecchia*^a and Ignacio E. León

*^a

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^a Centro de Química Inorgánica (CEQUINOR, CONICET-UNLP), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Bv 120 1465, 1900 La Plata, Argentina
E-mail: ileon@biol.unlp.edu.ar, lavecchia@quimica.unlp.edu.ar

Abstract

The study of novel mechanisms of action of vanadium compounds is critical to elucidating the role and importance of these kinds of compounds as antitumor and antimetastatic agents. This work deals with in silico and in vitro studies of one clioquinol oxidovanadium(IV) complex [VO(clioquinol)₂], VO(CQ)₂, and its regulation of FAK. In particular, we focus on elucidating the relationship of the FAK inhibition, MMP activity and antimetastatic effects of the complex in human bone cancer cells.

Metallomics

In silico and in vitro analysis of FAK/MMP signaling axis inhibition by VO-clioquinol in 2D and 3D human osteosarcoma cancer cells†

Abstract

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