In this work, two Cu(II)-based coordination polymers with the chemical formulae of [Cu(333cptpy)2]n·2nH2O (1, H333cptpy = 4′-(3-carboxyphenyl)-3,2′:6′,3″-terpyridine) and [Cu(233cptpy)2(H2O)2]n (2, H233cptpy = 4′-(2-carboxyphenyl)-3,2′:6′,3″-terpyridine) are hydrothermally synthesized using two positionally isomeric pyridyl-carboxylate ligands. The two as-prepared complexes are studied via X-ray single crystal diffraction along with the elemental analysis. Furthermore, the protective effect of compounds 1 and 2 against neonatal sepsis is evaluated. Firstly, ELISA is performed to detect the content of the C-reactive protein (CRP) in the serum of newborns after treatment with compounds 1 and 2. Next, the inflammatory level in the body is detected by the RT-PCR measurement of nf-κb and tnf-α.

中文翻译：

---

两种基于 Cu(II) 的配位聚合物：结构多样性和通过增强免疫系统的抗菌反应来治疗新生儿败血症的活性

在这项工作中，两种基于 Cu(II) 的配位聚合物的化学式为 [Cu(333cptpy)2]n·2nH2O (1, H333cptpy = 4'-(3-carboxyphenyl)-3,2':6', 3”-三联吡啶）和 [Cu(233cptpy)2(H2O)2]n (2, H233cptpy = 4'-(2-carboxyphenyl)-3,2':6',3"-terpyridine) 使用两种水热法合成位置异构的吡啶基羧酸盐配体。通过 X 射线单晶衍射和元素分析研究了两种制备的配合物。此外，还评估了化合物 1 和 2 对新生儿败血症的保护作用。首先进行ELISA检测用化合物1和2治疗后的新生儿血清中C反应蛋白（CRP）的含量。然后通过RT-PCR测量nf- κb 和 tnf-α。