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TWO Cu(II)-BASED COORDINATION POLYMERS: STRUCTURAL DIVERSITY AND TREATMENT ACTIVITY AGAINST NEONATAL SEPSIS BY ENHANCING THE ANTIBACTERIAL RESPONSE OF THE IMMUNE SYSTEM

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Abstract

In this work, two Cu(II)-based coordination polymers with the chemical formulae of [Cu(333cptpy)2]n·2nH2O (1, H333cptpy = 4′-(3-carboxyphenyl)-3,2′:6′,3″-terpyridine) and [Cu(233cptpy)2(H2O)2]n (2, H233cptpy = 4′-(2-carboxyphenyl)-3,2′:6′,3″-terpyridine) are hydrothermally synthesized using two positionally isomeric pyridyl-carboxylate ligands. The two as-prepared complexes are studied via X-ray single crystal diffraction along with the elemental analysis. Furthermore, the protective effect of compounds 1 and 2 against neonatal sepsis is evaluated. Firstly, ELISA is performed to detect the content of the C-reactive protein (CRP) in the serum of newborns after treatment with compounds 1 and 2. Next, the inflammatory level in the body is detected by the RT-PCR measurement of nf-κb and tnf-α.

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Authors and Affiliations

  1. Newborn Pediatrics, People′s Hospital of Wuwei, Wuwei, Gansu, P.R. China

    J. Qiu & W. -X. Zhang

  2. Clinical College of Chinese Medicine, Hubei University of Chinese Medicine, Wuhan, Wubei, P.R. China

    X. -X. Wang

  3. Integrated TCM and Western Medicine, Hubei Cancer Hospital, Wuhan, Wubei, P.R. China

    X. -X. Wang

  4. Huludao Financial Development Bureau, Huludao, Liaoning, P.R. China

    X. Gong

  5. Huludao Military-Civilian Integration and New Material Industry Development Center, Liaoning, P.R. China

    X. Gong

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  1. J. Qiu
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  2. X. -X. Wang
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  3. X. Gong
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  4. W. -X. Zhang
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Correspondence to W. -X. Zhang.

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Qiu, J., Wang, X.X., Gong, X. et al. TWO Cu(II)-BASED COORDINATION POLYMERS: STRUCTURAL DIVERSITY AND TREATMENT ACTIVITY AGAINST NEONATAL SEPSIS BY ENHANCING THE ANTIBACTERIAL RESPONSE OF THE IMMUNE SYSTEM. J Struct Chem 61, 1454–1460 (2020). https://doi.org/10.1134/S0022476620090139

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  • DOI: https://doi.org/10.1134/S0022476620090139

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