In this study, novel zwitterionic diblock copolymers, namely poly(2-(N-morpholino)ethyl methacrylate))-block-poly(2-(methacryloyloxy)ethyl phosphate) (PMEMA-b-PMOEP) and poly(2-(N-morpholino)ethyl methacrylate))-block-poly ((methacryloyloxy)methyl phosphonic acid) (PMEMA-b-PMOMP), were synthesized via reversible addition-fragmentation chain transfer controlled radical polymerization. Solution properties of these phosphorus-based diblock copolymers were investigated using dynamic light scattering, transmission electron microscopy and proton nuclear magnetic resonance spectroscopy. Since the PMEMA block has both salt- and thermo-responsive properties, PMEMA-b-PMOEP and PMEMA-b-PMOMP diblock copolymers formed core-shell micelles in basic aqueous media as the PMEMA block formed insoluble micelle core with the addition of Na₂SO₄ or an increase in temperature in basic solution. Additionally, PMEMA-b-PMOMP diblock copolymers interacted strongly with calcium cations and yielded reverse micellar structures via complexation of phosphate with metal cation in aqueous media.

在这项研究中，新颖的两性离子二嵌段共聚物，即聚（2-（Ñ吗啉代）乙酯）） -嵌段-聚（2-（甲基丙烯酰氧基）乙基磷酸酯）（PMEMA- b -PMOEP）和聚（2-（Ñ吗啉代）乙基甲基丙烯酸酯）） -嵌段-聚（（甲基丙烯酰）甲基膦酸）（PMEMA- b -PMOMP），合成通过受控的自由基聚合可逆加成-断裂链转移。使用动态光散射，透射电子显微镜和质子核磁共振波谱研究了这些基于磷的二嵌段共聚物的溶液性质。由于PMEMA嵌段同时具有盐响应和热响应特性，因此PMEMA-b- PMOEP和PMEMA- b- PMOMP二嵌段共聚物在碱性水性介质中形成核-壳胶束，因为PMEMA嵌段在添加Na ₂ SO ₄或碱性溶液中温度升高的情况下形成不溶性胶束核。另外，PMEMA- b- PMOMP二嵌段共聚物与钙阳离子强烈相互作用，并通过磷酸盐与金属阳离子在水性介质中的络合产生反向胶束结构。