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Preparation of Responsive Zwitterionic Diblock Copolymers Containing Phosphate and Phosphonate Groups

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Abstract

In this study, novel zwitterionic diblock copolymers, namely poly(2-(N-morpholino)ethyl methacrylate))-block-poly(2-(methacryloyloxy)ethyl phosphate) (PMEMA-b-PMOEP) and poly(2-(N-morpholino)ethyl methacrylate))-block-poly ((methacryloyloxy)methyl phosphonic acid) (PMEMA-b-PMOMP), were synthesized via reversible addition-fragmentation chain transfer controlled radical polymerization. Solution properties of these phosphorus-based diblock copolymers were investigated using dynamic light scattering, transmission electron microscopy and proton nuclear magnetic resonance spectroscopy. Since the PMEMA block has both salt- and thermo-responsive properties, PMEMA-b-PMOEP and PMEMA-b-PMOMP diblock copolymers formed core-shell micelles in basic aqueous media as the PMEMA block formed insoluble micelle core with the addition of Na2SO4 or an increase in temperature in basic solution. Additionally, PMEMA-b-PMOMP diblock copolymers interacted strongly with calcium cations and yielded reverse micellar structures via complexation of phosphate with metal cation in aqueous media.

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Authors and Affiliations

  1. Department of Chemistry and Chemical Process Technologies, Vocational School of Higher Education, Bilecik Seyh Edebali University, 11210, Bilecik, Turkey

    Yasemin Samav

  2. Department of Chemistry, Facullty of Science and Letters, Eskisehir Osmangazi University, 26040, Eskisehir, Turkey

    Yasemin Samav, Bernice Akpinar & Vural Bütün

  3. Department of Chemistry and Chemical Process Technologies, Vocational School of Higher Education, Adiyaman University, 02040, Adiyaman, Turkey

    Gökhan Kocak

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  1. Yasemin Samav
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  2. Bernice Akpinar
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  3. Gökhan Kocak
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  4. Vural Bütün
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Correspondence to Vural Bütün.

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Supporting information

Information is available regarding the experimental procedure for the synthesis of monomers and diblock copolymers and their characterizations. The materials are available via the Internet at http://www.springer.com/13233.

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Footnote: The image from this article is used as the cover image of the Volume 28, Issue 12.

Acknowledgments: Y. Samav thanks The Scientific and Technological Research Council of Turkey for the financial support given under its BIDEB 2211-A Domestic Graduate Scholarship Program.

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Samav, Y., Akpinar, B., Kocak, G. et al. Preparation of Responsive Zwitterionic Diblock Copolymers Containing Phosphate and Phosphonate Groups. Macromol. Res. 28, 1134–1141 (2020). https://doi.org/10.1007/s13233-020-8148-3

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  • DOI: https://doi.org/10.1007/s13233-020-8148-3

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