We report the development of an operationally straigtforward, visible-light-mediated multicomponent strategy for the construction of β-trifluoromethylated tertiary alkylamines from feedstock aldehydes, secondary amines and a convenient source of trifluoromethyl iodide. The new process does not require a photocatalyst, is metal-free, displays a broad functional group tolerance and offers rapid, one-pot access to trifluoromethylated drug-like compounds that will be of interest in medicinal chemistry.

中文翻译：

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可见光介导的羰基三氟甲基化胺化反应作为合成β-三氟甲基叔烷基胺的实用方法

我们报道了从原料醛，仲胺和三氟甲基碘的方便来源构建β-三氟甲基化叔烷基胺的操作策略，可见光介导的多组分战略的发展。新方法不需要光催化剂，不含金属，对官能团的耐受性广，并且可以快速，一锅地获得三氟甲基化的药物样化合物，这些化合物将在药物化学中引起人们的兴趣。