Issue 44, 2020
From the journal:

Chemical Science

Visible-light mediated carbonyl trifluoromethylative amination as a practical method for the synthesis of β-trifluoromethyl tertiary alkylamines†

Kavoos Kolahdouzan,a   Roopender Kumar ORCID logo a  and  Matthew J. Gaunt ORCID logo *a  

* Corresponding authors

a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
E-mail: mjg32@cam.ac.uk

Abstract

We report the development of an operationally straigtforward, visible-light-mediated multicomponent strategy for the construction of β-trifluoromethylated tertiary alkylamines from feedstock aldehydes, secondary amines and a convenient source of trifluoromethyl iodide. The new process does not require a photocatalyst, is metal-free, displays a broad functional group tolerance and offers rapid, one-pot access to trifluoromethylated drug-like compounds that will be of interest in medicinal chemistry.

Graphical abstract: Visible-light mediated carbonyl trifluoromethylative amination as a practical method for the synthesis of β-trifluoromethyl tertiary alkylamines

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Article information

DOI
https://doi.org/10.1039/D0SC04853D
Article type
Edge Article
Submitted
02 Sep 2020
Accepted
08 Oct 2020
First published
09 Oct 2020
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2020,11, 12089-12094

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Visible-light mediated carbonyl trifluoromethylative amination as a practical method for the synthesis of β-trifluoromethyl tertiary alkylamines

K. Kolahdouzan, R. Kumar and M. J. Gaunt, Chem. Sci., 2020, 11, 12089 DOI: 10.1039/D0SC04853D

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