Parkinson’s disease (PD) is a heterogeneous neurodegenerative disorder, characterized by depletion of dopamine resulted from the death of dopaminergic neurons in the substantia nigra . The prevalence and incidence of PD is influenced by several factors, such as age, gender, ethnicity, genetic susceptibilities, and environmental exposures. Coconut oil (Coc) is a rich source of medium-chain triglycerides that are easily metabolized and give rise to ketones. Also, it contains antioxidants, such as vitamin E and polyphenolic compounds. It has been documented that Coc possesses significant pharmacological activities against obesity, insulin resistance, and neurodegenerative disorders, like Alzheimer’s disease and multiple sclerosis. Therefore, the purpose of this review was to describe the use of coconut oil in preventing PD and slowing its progression. Also, we tried to identify possible mechanisms by which Coc may exert its beneficial role in PD. The available literature related to Coc PD effects , in both animal models and clinical trials was screened. This review showed that Coc can be supplemented to decrease the risk of PD.

中文翻译：

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椰子油治疗帕金森病的有益作用

帕金森病 (PD) 是一种异质性神经退行性疾病，其特征是黑质多巴胺能神经元死亡导致多巴胺耗竭。PD 的患病率和发病率受多种因素的影响，例如年龄、性别、种族、遗传易感性和环境暴露。椰子油 (Coc) 是中链甘油三酯的丰富来源，易于代谢并生成酮。此外，它还含有抗氧化剂，如维生素 E 和多酚化合物。已有文献证明，Coc 对肥胖、胰岛素抵抗和神经退行性疾病（如阿尔茨海默病和多发性硬化症）具有显着的药理活性。因此，本综述的目的是描述椰子油在预防 PD 和减缓其进展方面的用途。此外，我们试图确定 Coc 在 PD 中发挥其有益作用的可能机制。筛选了在动物模型和临床试验中与 Coc PD 效应相关的可用文献。该综述表明可以补充 Coc 以降低 PD 的风险。