The white matter state in migraine has been investigated using diffusion tensor imaging (DTI) measures, but results using this technique are conflicting. To overcome DTI measures, we employed ensemble average diffusion propagator measures obtained with apparent measures using reduced acquisitions (AMURA). The AMURA measures were return-to-axis (RTAP), return-to-origin (RTOP) and return-to-plane probabilities (RTPP). Tract-based spatial statistics was used to compare fractional anisotropy, mean diffusivity, axial diffusivity and radial diffusivity from DTI, and RTAP, RTOP and RTPP, between healthy controls, episodic migraine and chronic migraine patients. Fifty healthy controls, 54 patients with episodic migraine and 56 with chronic migraine were assessed. Significant differences were found between both types of migraine, with lower axial diffusivity values in 38 white matter regions and higher RTOP values in the middle cerebellar peduncle in patients with a chronic migraine (p < 0.05 family-wise error corrected). Significantly lower RTPP values were found in episodic migraine patients compared to healthy controls in 24 white matter regions (p < 0.05 family-wise error corrected), finding no significant differences using DTI measures. The white matter microstructure is altered in a migraine, and in chronic compared to episodic migraine. AMURA can provide additional results with respect to DTI to uncover white matter alterations in migraine.

中文翻译：

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标准MRI采集在偏头痛研究中补充弥散张量成像的替代性微结构措施

已经使用扩散张量成像（DTI）措施研究了偏头痛中的白质状态，但是使用该技术的结果却相矛盾。为了克服DTI措施，我们采用了集合平均扩散传播器措施，这些措施是使用减少采办量（AMURA）采取明显措施获得的。AMURA度量是轴返回（RTAP），原点返回（RTOP）和面返回概率（RTPP）。基于轨迹的空间统计数据用于比较健康对照，发作性偏头痛和慢性偏头痛患者之间的DTI，RTAP，RTOP和RTPP的分数各向异性，平均扩散率，轴向扩散率和径向扩散率。评估了五十名健康对照者，54例发作性偏头痛患者和56例慢性偏头痛患者。两种偏头痛之间存在显着差异，p <0.05家庭校正的错误）。与健康对照组相比，在24个白质区域中，发作性偏头痛患者的RTPP值显着降低（p <0.05家庭错误校正），使用DTI测度无明显差异。与发作性偏头痛相比，偏头痛中的白质微观结构发生了变化，在慢性中白质的微观结构发生了变化。AMURA可以提供有关DTI的其他结果，以发现偏头痛中的白质变化。