Self-detachable UV-curable polymers for open-access microfluidic platforms,Lab on a Chip

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Self-detachable UV-curable polymers for open-access microfluidic platforms
Lab on a Chip ( IF 6.1 ) Pub Date : 2020-10-02 , DOI: 10.1039/d0lc00604a
Dongha Tahk ₁ , Seokyoung Bang ₂ , Sujin Hyung ₁ , Jungeun Lim ₁ , James Yu ₃ , Jinhyun Kim ₂ , Noo Li Jeon ₄ , Hong Nam Kim ₅

Affiliation

This study presents an ultraviolet (UV)-curable polymer which is applicable to open-access microfluidic platforms. The UV-curable polymer was prepared by mixing trimethylolpropane triacrylate (TMPTA), 1,6-hexanediol diacrylate (HDDA), polyethylene glycol-diacrylate (PEG-DA), and Irgacure 184. The polymer resin is optically transparent before and after UV-assisted curing and showed good biocompatibility when culturing multiple types of cells on the nanopatterned polymer substrate. The polymer has good adhesion with poly(dimethylsiloxane) (PDMS) even under large deformation and showed a low swelling ratio when exposed to water, suggesting a possibility to be used as a substrate for an organ on a chip. Furthermore, because the polymers have controllable hydrolysis ability depending on the composition, long-term 3D cell culture and subsequent biological analysis with harvested cells are possible. The self-detachable synthesized UV-curable polymer may help the advancement of biomedical studies using in vitro cell culture.

中文翻译：

适用于开放式微流控平台的自分离型紫外线固化聚合物

这项研究提出了一种紫外线（UV）固化聚合物，适用于开放式微流控平台。通过将三羟甲基丙烷三丙烯酸酯（TMPTA），1,6-己二醇二丙烯酸酯（HDDA），聚乙二醇二丙烯酸酯（PEG-DA）和Irgacure 184混合来制备可紫外光固化的聚合物。该聚合物树脂在UV-固化前后是光学透明的当在纳米图案化的聚合物基质上培养多种类型的细胞时，可帮助固化并显示出良好的生物相容性。该聚合物即使在大变形下也具有与聚二甲基硅氧烷（PDMS）的良好粘附性，并且当暴露于水时显示出低溶胀率，这表明有可能用作芯片上的器官的底物。此外，由于聚合物根据组成具有可控制的水解能力，长期3D细胞培养以及随后对收获的细胞进行生物学分析是可能的。自分离合成的紫外线固化聚合物可能有助于生物医学研究的发展体外细胞培养。

更新日期：2020-11-03

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