Self-detachable UV-curable polymers for open-access microfluidic platforms

Dongha Tahk; Seokyoung Bang; Sujin Hyung; Jungeun Lim; James Yu; Jinhyun Kim; Noo Li Jeon; Hong Nam Kim

doi:10.1039/D0LC00604A

Self-detachable UV-curable polymers for open-access microfluidic platforms†

Dongha Tahk,

‡*^a Seokyoung Bang,

‡^b Sujin Hyung,

^a Jungeun Lim,^a James Yu,^c Jinhyun Kim,^b Noo Li Jeon

*^acde and Hong Nam Kim

*^bf

Author affiliations

* Corresponding authors

^a Department of Mechanical Engineering, Seoul National University, Seoul 08826, Republic of Korea
E-mail: tdhpride1@gmail.com, njeon@snu.ac.kr

^b Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea
E-mail: hongnam.kim@kist.re.kr

^c Interdisciplinary Program for Program for Bioengineering, Seoul National University, Seoul, Republic of Korea

^d World Class University Program on Multiscale Mechanical Design, Seoul National University, Seoul 08826, Republic of Korea

^e Institute of Advanced Machines and Design, Seoul National University, Seoul 08826, Republic of Korea

^f Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul 02792, Republic of Korea

Abstract

This study presents an ultraviolet (UV)-curable polymer which is applicable to open-access microfluidic platforms. The UV-curable polymer was prepared by mixing trimethylolpropane triacrylate (TMPTA), 1,6-hexanediol diacrylate (HDDA), polyethylene glycol-diacrylate (PEG-DA), and Irgacure 184. The polymer resin is optically transparent before and after UV-assisted curing and showed good biocompatibility when culturing multiple types of cells on the nanopatterned polymer substrate. The polymer has good adhesion with poly(dimethylsiloxane) (PDMS) even under large deformation and showed a low swelling ratio when exposed to water, suggesting a possibility to be used as a substrate for an organ on a chip. Furthermore, because the polymers have controllable hydrolysis ability depending on the composition, long-term 3D cell culture and subsequent biological analysis with harvested cells are possible. The self-detachable synthesized UV-curable polymer may help the advancement of biomedical studies using in vitro cell culture.

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DOI: https://doi.org/10.1039/D0LC00604A
Article type: Paper
Submitted: 11 Jun 2020
Accepted: 01 Oct 2020
First published: 02 Oct 2020

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Lab Chip, 2020,20, 4215-4224

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Self-detachable UV-curable polymers for open-access microfluidic platforms

D. Tahk, S. Bang, S. Hyung, J. Lim, J. Yu, J. Kim, N. L. Jeon and H. N. Kim, Lab Chip, 2020, 20, 4215 DOI: 10.1039/D0LC00604A

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Self-detachable UV-curable polymers for open-access microfluidic platforms†

Abstract

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Self-detachable UV-curable polymers for open-access microfluidic platforms

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