Cancer cells must adapt metabolism to thrive despite nutrient limitations in the tumor microenvironment. In this issue of Genes & Development, King and colleagues (pp. 1345–1358) report a role for transcriptional regulators of the Hippo pathway to facilitate protein scavenging and support proliferation under some nutrient-deprived conditions.

中文翻译：

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营养限制后河马途径对巨胞饮作用的转录激活

尽管肿瘤微环境中的营养成分有限，癌细胞仍必须使新陈代谢适应繁盛。在本期《基因与发展》中，King及其同事（第1345至1358页）报道了Hippo途径的转录调节因子在某些营养缺乏条件下促进蛋白质清除并支持增殖的作用。