Transcriptional activation of macropinocytosis by the Hippo pathway following nutrient limitation
- 1Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA;
- 2Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
- Corresponding author: mvh{at}mit.edu
Abstract
Cancer cells must adapt metabolism to thrive despite nutrient limitations in the tumor microenvironment. In this issue of Genes & Development, King and colleagues (pp. 1345–1358) report a role for transcriptional regulators of the Hippo pathway to facilitate protein scavenging and support proliferation under some nutrient-deprived conditions.
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Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.343632.120.
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