Autophagy is an evolutionary conserved and highly regulated recycling process of cellular wastes. Having a housekeeping role, autophagy through the digestion of domestic cytosolic organelles, proteins, macromolecules, and pathogens, eliminates unnecessary materials and provides nutrients and energy for cell survival and maintenance. The critical role of autophagy and autophagy-related proteins in osteoclast differentiation, bone resorption, and maintenance of bone homeostasis has previously been reported. Increasing evidence reveals that autophagy dysregulation leads to alteration of osteoclast function and enhanced bone loss, which is associated with the onset and progression of osteoporosis. In this review, we briefly consolidate the current state-of-the-art technology regarding the role of autophagy in osteoclast function in both physiologic and pathologic conditions to have a more general view on this issue.

中文翻译：

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自噬在破骨细胞分化和骨吸收功能中的作用


自噬是一种进化保守且高度调控的细胞废物回收过程。自噬具有看家的作用，通过消化体内的细胞器、蛋白质、大分子和病原体，消除不必要的物质，并为细胞的生存和维持提供营养和能量。自噬和自噬相关蛋白在破骨细胞分化、骨吸收和骨稳态维持中的关键作用先前已有报道。越来越多的证据表明，自噬失调会导致破骨细胞功能改变和骨质流失增加，这与骨质疏松症的发生和进展有关。在这篇综述中，我们简要总结了当前关于自噬在生理和病理条件下破骨细胞功能中的作用的最先进技术，以便对这个问题有更全面的看法。