The Role of Autophagy in Osteoclast Differentiation and Bone Resorption Function
Abstract
:1. Bone Remodeling
2. Autophagy and Bone Remodeling
3. Autophagy in Osteoclast Differentiation/Function
3.1. Regulation of Osteoclast Differentiation by Autophagy
3.2. Regulation of Osteoclast Migration by Autophagy
3.3. Regulation of Bone Resorption by Autophagy
4. The Role of Autophagy in Bone Disorders
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Knock Downed Gene | Effect on Bone Cells |
---|---|
ATG5 | Reduction of osteoblast and osteoclast differentiation [53] |
ATG7 | Reduction of osteoblast differentiation [54] Impaired cathepsin K secretion by osteoclast and impaired bone resorption [55] Osteocyte-mediated induction of aging-like phenotype [54,56] |
Beclin | Reduction of mineralization activity by osteoblasts [57] |
LC3 | Impairment of bone resorption [58] |
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Montaseri, A.; Giampietri, C.; Rossi, M.; Riccioli, A.; Del Fattore, A.; Filippini, A. The Role of Autophagy in Osteoclast Differentiation and Bone Resorption Function. Biomolecules 2020, 10, 1398. https://doi.org/10.3390/biom10101398
Montaseri A, Giampietri C, Rossi M, Riccioli A, Del Fattore A, Filippini A. The Role of Autophagy in Osteoclast Differentiation and Bone Resorption Function. Biomolecules. 2020; 10(10):1398. https://doi.org/10.3390/biom10101398
Chicago/Turabian StyleMontaseri, Azadeh, Claudia Giampietri, Michela Rossi, Anna Riccioli, Andrea Del Fattore, and Antonio Filippini. 2020. "The Role of Autophagy in Osteoclast Differentiation and Bone Resorption Function" Biomolecules 10, no. 10: 1398. https://doi.org/10.3390/biom10101398