The main objective of current work was to determine the effects of treadmill-running and swimming exercise on passive avoidance learning (PAL) and blood biochemical parameters in rats with streptozotocin (STZ)-induced diabetes. Male Wistar rats were divided into the following 6 groups (N = 6–8 per group): CON, healthy rats without exercise (N = 8); STZ, diabetic rats without exercise (N = 8); CON-SE, healthy rats subjected to swimming exercise (2 months; N = 6); STZ-SE, diabetic rats subjected to swimming exercise (2 months; N = 7); CON-TE, healthy rats subjected to treadmill exercise (2 months; N = 8); STZ-TE, diabetic rats subjected to treadmill exercise (2 months; N = 8). Diabetes was induced by a single intraperitoneal injection of 50 mg/kg STZ. Our results showed that STZ decreased the step-through latency in the retention test (STLr) and increased the time spent in the dark compartment (TDC) when compared with the CON group. However, treadmill-running and swimming exercise in STZ-treated rats increased the STLr and decreased the TDC when compared with STZ-treated rats without exercise in PAL. Blood low-density lipoprotein (LDL) and triglyceride (TG) levels in the STZ group were significantly higher than those in the CON group, whereas plasma total antioxidant capacity (TAC) and levels of catalase (CAT) and glutathione peroxidase (GPx) were lower in the STZ group compared with the CON group. The levels of LDL and TG decreased and the levels of TAC, CAT, and GPx increased in the exercise groups in comparison with the STZ group. The present results indicate that regular exercise enhances learning and memory in diabetic rats and that these effects may occur through activation of the antioxidant system.

当前工作的主要目的是确定跑步机跑步和游泳运动对链脲佐菌素 (STZ) 诱导的糖尿病大鼠被动回避学习 (PAL) 和血液生化参数的影响。雄性 Wistar 大鼠分为以下 6 组（每组N  = 6-8）： CON，未运动的健康大鼠（N  = 8）；STZ，未运动的糖尿病大鼠（N  = 8）；CON-SE，进行游泳运动的健康大鼠（2 个月；N  = 6）；STZ-SE，接受游泳运动的糖尿病大鼠（2 个月；N  = 7）；CON-TE，进行跑步机运动的健康大鼠（2 个月；N  = 8）；STZ-TE，糖尿病大鼠进行跑步机运动（2 个月；N = 8）。通过单次腹膜内注射 50 mg/kg STZ 诱发糖尿病。我们的结果表明，与 CON 组相比，STZ 减少了保留测试 (STLr) 中的步进延迟，并增加了在暗室 (TDC) 中花费的时间。然而，与未进行 PAL 运动的 STZ 治疗大鼠相比，STZ 治疗大鼠的跑步机跑步和游泳运动增加了 STLr 并降低了 TDC。STZ组血液低密度脂蛋白（LDL）和甘油三酯（TG）水平显着高于CON组，而血浆总抗氧化能力（TAC）和过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GPx）水平显着高于CON组。 STZ 组低于 CON 组。LDL和TG水平下降，TAC、CAT、与 STZ 组相比，运动组的 GPx 增加。目前的结果表明，有规律的运动可以增强糖尿病大鼠的学习和记忆力，这些影响可能是通过激活抗氧化系统而发生的。