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Effects of Regular Exercise on Diabetes-Induced Memory Deficits and Biochemical Parameters in Male Rats

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Abstract

The main objective of current work was to determine the effects of treadmill-running and swimming exercise on passive avoidance learning (PAL) and blood biochemical parameters in rats with streptozotocin (STZ)-induced diabetes. Male Wistar rats were divided into the following 6 groups (N = 6–8 per group): CON, healthy rats without exercise (N = 8); STZ, diabetic rats without exercise (N = 8); CON-SE, healthy rats subjected to swimming exercise (2 months; N = 6); STZ-SE, diabetic rats subjected to swimming exercise (2 months; N = 7); CON-TE, healthy rats subjected to treadmill exercise (2 months; N = 8); STZ-TE, diabetic rats subjected to treadmill exercise (2 months; N = 8). Diabetes was induced by a single intraperitoneal injection of 50 mg/kg STZ. Our results showed that STZ decreased the step-through latency in the retention test (STLr) and increased the time spent in the dark compartment (TDC) when compared with the CON group. However, treadmill-running and swimming exercise in STZ-treated rats increased the STLr and decreased the TDC when compared with STZ-treated rats without exercise in PAL. Blood low-density lipoprotein (LDL) and triglyceride (TG) levels in the STZ group were significantly higher than those in the CON group, whereas plasma total antioxidant capacity (TAC) and levels of catalase (CAT) and glutathione peroxidase (GPx) were lower in the STZ group compared with the CON group. The levels of LDL and TG decreased and the levels of TAC, CAT, and GPx increased in the exercise groups in comparison with the STZ group. The present results indicate that regular exercise enhances learning and memory in diabetic rats and that these effects may occur through activation of the antioxidant system.

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Acknowledgments

The authors would like to express their gratitude to the staff of the Neurophysiology Research Center for helping us to carry out this project.

Funding

This research was supported by a grant (Grant number: IR.UMSHA.REC.1395.26) of the Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.

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Authors and Affiliations

  1. Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran

    Seyed Asaad Karimi, Iraj Salehi, Nafiseh Faraji & Alireza Komaki

  2. Department of Neuroscience, School of Advanced Technologies in Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

    Seyed Asaad Karimi & Alireza Komaki

  3. Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Mohammad Taheri

  4. Department of Physiology, School of Medicine, Hamadan University of Medical Sciences, Shahid Fahmideh Street, Hamadan, 65178/518, Iran

    Nafiseh Faraji & Alireza Komaki

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  1. Seyed Asaad Karimi
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Correspondence to Nafiseh Faraji or Alireza Komaki.

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All research and animal care procedures were approved by the Veterinary Ethics Committee of the Hamadan University of medical science and were performed in accordance with the National Institutes of Health Guide for Care and Use of Laboratory Animals (NIH Publication No. 85–23, revised 1985).

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Karimi, S.A., Salehi, I., Taheri, M. et al. Effects of Regular Exercise on Diabetes-Induced Memory Deficits and Biochemical Parameters in Male Rats. J Mol Neurosci 71, 1023–1030 (2021). https://doi.org/10.1007/s12031-020-01724-3

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