In male rats, acute renal failure was simulated by clamping the vascular pedicle of the left kidney for 60 or 90 min and right-sided nephrectomy. In the control series, no therapy was performed. In the experimental series, the animals were daily injected subcutaneously with Cellex, a protein-peptide complex (PPC) chromatographically isolated from the brain tissue of pig embryos with a molecular weight of its components from 10 to 250 kDa. PPC was administered 5 times a week (10 injections) in a dose of 0.1 ml/kg (0.1 mg active substance per 1 kg body weight). Ischemia of a single kidney led to the development of acute renal failure, more severe after 90-min ischemia. PPC therapy reduced the severity of functional disorders mainly at the early stages (3 and 7 days) with normalization of blood concentrations of urea and creatinine, creatinine clearance, tubular reabsorption of sodium and calcium, including the cases with 90-min ischemia, which did not occur in the control series. PPC therapy also contributed to hypertrophy of many glomeruli, prevented the development of glomerulosclerosis, and reduced damage to the epithelium of the renal tubules. At the same time, neither pronounced lymphohistiocytic infiltration, nor focal nephrosclerosis typical of control series were observed.

中文翻译：

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胚胎蛋白肽复合疗法对不同严重程度缺血后急性肾功能衰竭大鼠肾脏结构和功能恢复的刺激作用

在雄性大鼠中，通过夹住左肾血管蒂 60 或 90 分钟和右侧肾切除术来模拟急性肾功能衰竭。在对照组中，没有进行任何治疗。在实验系列中，动物每天皮下注射 Cellex，这是一种蛋白质-肽复合物 (PPC)，从猪胚胎的脑组织中色谱分离，其成分的分子量为 10 至 250 kDa。PPC 每周给药 5 次（10 次注射），剂量为 0.1 ml/kg（每 1 kg 体重 0.1 mg 活性物质）。单个肾脏缺血导致急性肾功能衰竭，缺血 90 分钟后更严重。PPC 治疗主要在早期（3 天和 7 天）降低了功能障碍的严重程度，使尿素和肌酐的血液浓度恢复正常，肌酐清除率、钠和钙的肾小管重吸收，包括 90 分钟缺血的病例，这在对照组中没有发生。PPC 治疗还有助​​于许多肾小球肥大，防止肾小球硬化的发展，并减少对肾小管上皮的损伤。同时，没有观察到明显的淋巴组织细胞浸润，也没有观察到对照组典型的局灶性肾硬化。