We studied the level of heat shock protein HSP70 under conditions of oxidative stress in 47 patients with apnea. The control group included 13 healthy subjects without verified apnea. Blood serum, plasma, and erythrocyte hemolysate were used to determine LPO and anti-oxidant protection components by spectrophotometrical and spectrofluorometrical methods. HSP70 was assayed by ELISA. A direct relationship was established between the intensity of oxidative stress and HSP70 expression in patients with apnea. Quantitative determination of HSP70 can be used as a molecular marker in the early diagnosis and prognosis of the development of various pathological conditions in hypoxia.

中文翻译：

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热休克蛋白 HSP70 在呼吸暂停患者氧化应激中的作用

我们研究了 47 名呼吸暂停患者在氧化应激条件下的热休克蛋白 HSP70 水平。对照组包括 13 名未经证实呼吸暂停的健康受试者。通过分光光度法和荧光分光光度法，使用血清、血浆和红细胞溶血产物测定 LPO 和抗氧化保护成分。通过ELISA测定HSP70。在呼吸暂停患者的氧化应激强度和 HSP70 表达之间建立了直接关系。HSP70的定量测定可作为低氧条件下各种病理状况发展的早期诊断和预后的分子标志物。