The cerebrovascular properties of 3,4,6,7,8,9-hexahydrodibenzo[b,d]furan-1(2H)-one O-(4-cinnamoyl)oxime (C21H21NO3, GIZ-272) were studied. The ability of GIZ-272 to improve the brain blood supply in rats subjected to global transient ischemia and to a lesser extent in animals with a hemorrhagic stroke model was established. The compound had cerebrovascular anti-ischemic activity comparable to that of Mexidol and a duration of action longer than that of nimodipine. It is important to note that GIZ-272 did not cause a decrease in blood pressure and was superior to both Mexidol and nimodipine in this respect. An analysis of the cerebrovascular effect of GIZ-272 using bicucullin indicated that the GABA-ergic system of cerebral vessels participated in implementation of the anti-ischemic effect of the compound.

中文翻译：

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一种二苯并呋喃肟衍生物的脑血管作用分析

研究了 3,4,6,7,8,9-hexahydrodibenzo[b,d]furan-1(2H)-one O-(4-cinnamoyl)oxime (C21H21NO3, GIZ-272) 的脑血管特性。建立了 GIZ-272 改善全身短暂性缺血大鼠脑血供的能力，并在较小程度上改善出血性中风模型动物的脑血供。该化合物具有与 Mexidol 相当的脑血管抗缺血活性，作用持续时间长于尼莫地平。值得注意的是，GIZ-272 不会导致血压下降，在这方面优于 Mexidol 和尼莫地平。使用荷包牡丹碱对 GIZ-272 的脑血管作用进行分析表明，脑血管的 GABA 能系统参与了该化合物抗缺血作用的实现。