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Analysis of the Cerebrovascular Effect of a Dibenzofuran Oxime Derivative

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The cerebrovascular properties of 3,4,6,7,8,9-hexahydrodibenzo[b,d]furan-1(2H)-one O-(4-cinnamoyl)oxime (C21H21NO3, GIZ-272) were studied. The ability of GIZ-272 to improve the brain blood supply in rats subjected to global transient ischemia and to a lesser extent in animals with a hemorrhagic stroke model was established. The compound had cerebrovascular anti-ischemic activity comparable to that of Mexidol and a duration of action longer than that of nimodipine. It is important to note that GIZ-272 did not cause a decrease in blood pressure and was superior to both Mexidol and nimodipine in this respect. An analysis of the cerebrovascular effect of GIZ-272 using bicucullin indicated that the GABA-ergic system of cerebral vessels participated in implementation of the anti-ischemic effect of the compound.

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Authors and Affiliations

  1. V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences, 8 Baltiiskaya St, Moscow, 125315, Russia

    R. S. Mirzoyan, T. S. Gan’shina, I. N. Kurdyumov, E. V. Kurza, D. V. Maslennikov, A. I. Turilova & L. M. Zhmurenko

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  1. R. S. Mirzoyan
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  2. T. S. Gan’shina
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  3. I. N. Kurdyumov
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  4. E. V. Kurza
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  5. D. V. Maslennikov
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  6. A. I. Turilova
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  7. L. M. Zhmurenko
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 54, No. 6, pp. 20 – 23, June, 2020.

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Mirzoyan, R.S., Gan’shina, T.S., Kurdyumov, I.N. et al. Analysis of the Cerebrovascular Effect of a Dibenzofuran Oxime Derivative. Pharm Chem J 54, 564–567 (2020). https://doi.org/10.1007/s11094-020-02240-9

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  • DOI: https://doi.org/10.1007/s11094-020-02240-9

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