The awareness of malignant metabolism transformations has recently emerged. Since Otto Warburg found that tumor cells prefer glycolysis to oxidative phosphorylation even in the presence of oxygen, studies have shown that cancer cells also depend on upregulated fatty-acid synthesis and glutaminolysis. The present review covers the key metabolic enzymes known as metabolic oncogenes and suggests ways of modulating their activity. It is concluded that metabolic transformations during carcinogenesis present opportunities for targeted action on neoplasms and provide a new field for antitumor drug development.

中文翻译：

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代谢酶：抗肿瘤药物设计的新靶点

最近出现了对恶性代谢转变的认识。由于 Otto Warburg 发现肿瘤细胞即使在有氧的情况下也更喜欢糖酵解而不是氧化磷酸化，因此研究表明，癌细胞也依赖于上调的脂肪酸合成和谷氨酰胺分解。本综述涵盖了被称为代谢癌基因的关键代谢酶，并提出了调节其活性的方法。结论是，致癌过程中的代谢转化为靶向作用于肿瘤提供了机会，并为抗肿瘤药物开发提供了一个新领域。