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Metabolic Enzymes: New Targets for the Design of Antitumor Drugs

  • MOLECULAR-BIOLOGICAL PROBLEMS OF DRUG DESIGN AND MECHANISM OF DRUG ACTION
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Pharmaceutical Chemistry Journal Aims and scope

The awareness of malignant metabolism transformations has recently emerged. Since Otto Warburg found that tumor cells prefer glycolysis to oxidative phosphorylation even in the presence of oxygen, studies have shown that cancer cells also depend on upregulated fatty-acid synthesis and glutaminolysis. The present review covers the key metabolic enzymes known as metabolic oncogenes and suggests ways of modulating their activity. It is concluded that metabolic transformations during carcinogenesis present opportunities for targeted action on neoplasms and provide a new field for antitumor drug development.

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Author notes

  1. L. A. Braun, E. E. Varpetyan, G. A. Zav’yalov, F. V. Kulikov, V. E. Marievskii, D. A. Tyul’ganova and A. O. Shishnenko contributed equally to the article.

Authors and Affiliations

  1. N. I. Pirogov Russian National Research Medical University (Pirogov Medical University), Moscow, 117997, Russia

    L. A. Braun, E. E. Varpetyan, G. A. Zav’yalov, F. V. Kulikov, V. E. Marievskii, D. A. Tyul’ganova, A. O. Shishnenko, D. S. Stepanova & N. L. Shimanovskii

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  1. L. A. Braun
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  2. E. E. Varpetyan
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  3. G. A. Zav’yalov
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  4. F. V. Kulikov
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  5. V. E. Marievskii
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  8. D. S. Stepanova
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  9. N. L. Shimanovskii
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Correspondence to D. S. Stepanova.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 54, No. 6, pp. 3 – 10, June, 2020.

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Braun, L.A., Varpetyan, E.E., Zav’yalov, G.A. et al. Metabolic Enzymes: New Targets for the Design of Antitumor Drugs. Pharm Chem J 54, 547–554 (2020). https://doi.org/10.1007/s11094-020-02238-3

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  • DOI: https://doi.org/10.1007/s11094-020-02238-3

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