Abstract—We studied the dynamics of changes in the content of neuron specific enolase (NSE, EC 4.2.1.11) in the hippocampus, cortex, cerebellum and blood serum of rats at 5th, 10th, and 30th days of postnatal development. It was shown that during the first month of life the content of NSE increases several-fold in all the structures studied, both after hypoxia and in the animals not exposed to hypoxia. It was established that prenatal hypoxia on the 14th day of embryonic development leads to significant changes in the NSE content in all the brain structures studied. In the blood serum, the content of this enzyme is higher in comparison with the control group on the 5th, 10th, and 30th postnatal days in experimental animals. Thus, the lack of oxygen affects the content of this enzyme in both the brain structures and in blood serum of rats, which makes it possible to judge the survival of neurons under conditions of prenatal hypoxia, and also suggests that this index may be used as a marker of fetal CNS disturbance after hypoxia during prenatal development.

摘要—我们研究了出生后第5、10和30天大鼠海马，皮质，小脑和血清中神经元特异性烯醇化酶（NSE，EC 4.2.1.11）含量变化的动力学。结果表明，在出生后的头一个月，在所有研究的结构中，无论缺氧后还是未暴露于缺氧的动物​​，NSE的含量都会增加几倍。已经确定，胚胎发育第14天的产前缺氧会导致所研究的所有大脑结构中NSE含量的显着变化。在实验动物的出生后第5天，第10天和第30天，血清中该酶的含量与对照组相比更高。因此，缺氧会影响大鼠大脑结构和血清中该酶的含量，