This study aimed to investigate the effects of vitamin D and magnesium co-supplementation on muscle strength and function, body composition, and inflammation in vitamin D-deficient middle-aged women. In this study, 83 healthy middle-aged women (40-55 years) with vitamin D deficiency were randomly assigned into two groups: (1) intervention: receiving a 50,000-IU vitamin D soft gel (weekly) plus a 250-mg magnesium tablet (daily); (2) control: receiving a vitamin D placebo (weekly) plus a magnesium placebo (daily), for 8 weeks. Before and after the intervention, anthropometric indices, muscle strength, muscle function, and some inflammatory markers were measured. After 8 weeks of supplementation, significant difference was observed in handgrip strength and time for Time Get Up and Go (TGUG) test between the intervention and placebo groups (P < 0.05). Regarding percentage of fat mass (FM%) and fat free mass (FFM%), and knee extension strength, there was no significant difference between the two groups at the end of intervention (P > .05). Serum 25(OH)-D levels increased significantly (P < 0.001) and its change was significantly different between the two groups, at the end of the intervention (P < 0.001). Serum level of hs-CRP decreased significantly in the intervention group compared to baseline (P < 0.001), and the change in hs-CRP was significant between the two groups at the end of the intervention (P < 0.01). Furthermore, serum level of TNF-α declined significantly in the intervention group compared to baseline (P < 0.001) but, no significant differences were seen between the two groups in regard of serum levels of TNF-α and IL-6 after the intervention (P > 0.05). Our findings show that vitamin D and magnesium co-supplementation, for 8 weeks, in healthy middle-aged women with vitamin D deficiency have beneficial impacts on muscle strength, muscle function, and probably inflammation.

中文翻译：

---

维生素 D 和镁联合补充剂对缺乏维生素 D 的中年女性肌肉强度和功能、身体成分和炎症影响的随机研究。

本研究旨在调查维生素 D 和镁联合补充剂对缺乏维生素 D 的中年女性肌肉力量和功能、身体成分和炎症的影响。在这项研究中，83 名患有维生素 D 缺乏症的健康中年女性（40-55 岁）被随机分为两组：（1）干预：接受 50,000 IU 维生素 D 软凝胶（每周）加 250 毫克镁平板电脑（每天）；(2) 对照：接受维生素 D 安慰剂（每周）加镁安慰剂（每天），持续 8 周。在干预前后，测量人体测量指标、肌肉力量、肌肉功能和一些炎症标志物。补充 8 周后，干预组和安慰剂组之间的握力和时间起床（TGUG）测试时间有显着差异（P < 0. 05）。在脂肪量（FM%）和去脂量（FFM%）百分比以及伸膝强度方面，两组在干预结束时没有显着差异（P > .05）。在干预结束时，血清 25(OH)-D 水平显着增加（P < 0.001），并且其变化在两组之间有显着差异（P < 0.001）。与基线相比，干预组血清hs-CRP水平显着降低（P < 0.001），干预结束时两组间hs-CRP的变化显着（P < 0.01）。此外，与基线相比，干预组的血清TNF-α水平显着下降（P < 0.001），但干预后两组血清TNF-α和IL-6水平无显着差异（P < 0.001）。 P > 0.05）。