We studied the radioprotective effect of betaleukin administered to (CBA×C57Bl/6)F1 mice in single doses of 50 and 3 μg/kg 2 and 22 h, respectively, prior to long-term (21 h) whole-body low-intensity (10 mGy/min) γ-radiation (137Сs; total dose 12.65 Gy). Hepatocyte ploidy, a biomarker of metabolic disorders of the liver, was evaluated, and nuclearity and ploidy indices were calculated. In 10 months after irradiation, a significant decrease in the ploidy index was revealed in the group of irradiated mice, while in animal receiving 3 or 50 μg/kg betaleukin, this parameter did not differ and even surpassed the control level, respectively. Thus, in vivo assessment of hepatocytic ploidy profile in mice revealed negative delayed effects of γ-irradiation in a dose of 12.65 Gy and a protective effect a single injection of immunomodulator betaleukin.

中文翻译：

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免疫调节剂 Betaleukin 在照射后延迟期肝细胞倍性特征恢复中的作用

我们研究了在长期 (21 小时) 全身低强度照射之前，分别以 50 和 3 μg/kg 2 和 22 小时的单剂量给药于 (CBA×C57Bl/6)F1 小鼠的 betaleukin 的辐射防护作用(10 mGy/min) γ-辐射 (137Сs; 总剂量 12.65 Gy)。评估了肝细胞倍性（肝脏代谢紊乱的生物标志物），并计算了核数和倍性指数。辐照后10个月，辐照组小鼠倍性指数显着降低，而在接受3或50 μg/kg betaleukin的动物中，该参数没有差异，甚至分别超过对照水平。因此，小鼠肝细胞倍性特征的体内评估揭示了 12.65 Gy 剂量的 γ 辐射的负面延迟效应和单次注射免疫调节剂 betaleukin 的保护作用。