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The Role of Immunomodulator Betaleukin in Recovery of Hepatocytic Ploidy Profile in Delayed Terms after Irradiation

  • MICROBIOLOGY AND IMMUNOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the radioprotective effect of betaleukin administered to (CBA×C57Bl/6)F1 mice in single doses of 50 and 3 μg/kg 2 and 22 h, respectively, prior to long-term (21 h) whole-body low-intensity (10 mGy/min) γ-radiation (137Сs; total dose 12.65 Gy). Hepatocyte ploidy, a biomarker of metabolic disorders of the liver, was evaluated, and nuclearity and ploidy indices were calculated. In 10 months after irradiation, a significant decrease in the ploidy index was revealed in the group of irradiated mice, while in animal receiving 3 or 50 μg/kg betaleukin, this parameter did not differ and even surpassed the control level, respectively. Thus, in vivo assessment of hepatocytic ploidy profile in mice revealed negative delayed effects of γ-irradiation in a dose of 12.65 Gy and a protective effect a single injection of immunomodulator betaleukin.

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Authors and Affiliations

  1. A. I. Burnazyan State Research Centre Federal Medical Biophysical Center, Federal Medical Biological Agency, Moscow, Russia

    L. P. Sycheva & L. M. Rozhdestvenskii

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  1. L. P. Sycheva
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  2. L. M. Rozhdestvenskii
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Correspondence to L. P. Sycheva.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 169, No. 4, pp. 444-448, April, 2020

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Sycheva, L.P., Rozhdestvenskii, L.M. The Role of Immunomodulator Betaleukin in Recovery of Hepatocytic Ploidy Profile in Delayed Terms after Irradiation. Bull Exp Biol Med 169, 463–466 (2020). https://doi.org/10.1007/s10517-020-04909-3

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  • DOI: https://doi.org/10.1007/s10517-020-04909-3

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