Aortic stiffness represents the major cause of aging and tightly associated with hypertension, atherosclerosis, cardiovascular diseases, and increased mortality. Mechanical characteristics of the aorta play a vital role in the blood flow, circulation, systolic pressure, and aortic stiffness; however, the correlation of trace element and mineral levels with aortic stiffness has not been studied before. Balance in the trace elements and minerals is vital for the biological functions; however, natural aging may alter this balance. Thus, after measuring aortic stiffness of aged and young rat aortas by a custom-built stretcher device, trace element and mineral levels were evaluated via ICP-MS. Also, biomarkers of aging including blood pressure, arterial pressure glucose, insulin levels, and histochemical parameters were investigated as well. Aortic stiffness, blood glucose, plasma insulin, systolic, diastolic, and mean arterial pressure significantly increased by aging in the aorta of aged rats compared with the young ones. Also, Fe, Al, Co, Ni, Zn, Sr, Na, Mg, and K levels increased in the aged aorta samples compared with the young aorta samples of rats. Increased levels of the indicated elements may be correlated with the development and progression of aortic stiffness and vascular complications. Thus, possible mechanisms correlating aortic stiffness with the imbalance in the trace element and mineral levels should be further investigated.

主动脉僵硬是衰老的主要原因，与高血压、动脉粥样硬化、心血管疾病和死亡率增加密切相关。主动脉的机械特性对血流、循环、收缩压和主动脉僵硬起着至关重要的作用；然而，微量元素和矿物质水平与主动脉僵硬度的相关性以前没有研究过。微量元素和矿物质的平衡对生物功能至关重要；然而，自然老化可能会改变这种平衡。因此，在通过定制的担架装置测量老年和年轻大鼠主动脉的主动脉硬度后，通过 ICP-MS 评估微量元素和矿物质水平。此外，还研究了衰老的生物标志物，包括血压、动脉压葡萄糖、胰岛素水平和组织化学参数。与年轻大鼠相比，老年大鼠主动脉的主动脉僵硬度、血糖、血浆胰岛素、收缩压、舒张压和平均动脉压随着年龄的增长而显着增加。此外，与年轻的大鼠主动脉样品相比，老年主动脉样品中的 Fe、Al、Co、Ni、Zn、Sr、Na、Mg 和 K 水平增加。指示元素水平的增加可能与主动脉僵硬和血管并发症的发展和进展相关。因此，应进一步研究将主动脉僵硬与微量元素和矿物质水平失衡相关联的可能机制。与年轻的大鼠主动脉样品相比，老年主动脉样品中的 K 水平增加。指示元素水平的增加可能与主动脉僵硬和血管并发症的发展和进展相关。因此，应进一步研究将主动脉僵硬与微量元素和矿物质水平失衡相关联的可能机制。与年轻的大鼠主动脉样品相比，老年主动脉样品中的 K 水平增加。指示元素水平的增加可能与主动脉僵硬和血管并发症的发展和进展相关。因此，应进一步研究将主动脉僵硬与微量元素和矿物质水平失衡相关联的可能机制。