The hyphenation of Ultra-Performance Liquid performance (UPLC) with mass spectrometry (MS) has emerged as a powerful tool in analytical research due to its advanced sensitivity, resolution and speed. Its advanced instrumentation, specialized columns, separation at ultra-high pressure and sophisticated software are the distinguishing features as compared to the traditional separating techniques. It has a wide range of applications in various fields such as analysis of food stuffs, drug metabolites, beverages, toxicology, soil samples and micronutrient analysis. In the present compilation, authors have highlighted the applicability of UPLC-MS in the analysis of food stuffs and drug metabolites along with the various optimized analytical conditions and obtained results.

质谱（MS）与超高性能液相色谱联用（UPLC）具有先进的灵敏度，分辨率和速度，已成为分析研究中的强大工具。与传统的分离技术相比，其先进的仪器，专用的色谱柱，超高压分离和复杂的软件是其显着特征。它在食品，药物代谢物，饮料，毒理学，土壤样品和微量营养素分析等各个领域具有广泛的应用。在本汇编中，作者强调了UPLC-MS以及各种优化的分析条件和获得的结果在食品和药物代谢物分析中的适用性。