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Current Pharmaceutical Analysis

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ISSN (Online): 1875-676X

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Review Article

Impact of UPLC-MS in Food and Drug/Metabolite Analysis

Author(s): Ankit Semwal, Raghav Dogra, Kritika Verma and Rohit Bhatia*

Volume 17, Issue 1, 2021

Published on: 23 September, 2019

Page: [10 - 30] Pages: 21

DOI: 10.2174/1573412915666190923105355

Price: $65

Abstract

The hyphenation of Ultra-Performance Liquid performance (UPLC) with mass spectrometry (MS) has emerged as a powerful tool in analytical research due to its advanced sensitivity, resolution and speed. Its advanced instrumentation, specialized columns, separation at ultra-high pressure and sophisticated software are the distinguishing features as compared to the traditional separating techniques. It has a wide range of applications in various fields such as analysis of food stuffs, drug metabolites, beverages, toxicology, soil samples and micronutrient analysis. In the present compilation, authors have highlighted the applicability of UPLC-MS in the analysis of food stuffs and drug metabolites along with the various optimized analytical conditions and obtained results.

Keywords: UPLC-MS, sensitivity, food stuffs, drug metabolites, toxicology, HPLC.

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Graphical Abstract

[1]
Naushad, M.; Khan, M.R.; Alothman, Z.A. Ultra Performance Liquid Chromatography Mass Spectrometry Evaluation and Applications in Food Analysis, 1; Taylor & Francis, 2015, pp. 1-15.
[2]
Fenn, J.B.; Mann, M.; Meng, C.K.; Wong, S.F.; Whitehouse, C.M. Electrospray ionization for mass spectrometry of large biomolecules. Science, 1989, 246(4926), 64-71.
[http://dx.doi.org/10.1126/science.2675315] [PMID: 2675315]
[3]
Chawla, G.; Ranjan, C. Principle, instrumentation, and applications of UPLC: A novel technique of liquid chromatography. Open Chem. J., 2016, 3(1), 1-16.
[http://dx.doi.org/10.2174/1874842201603010001]
[4]
LCGC Solution for Seperation Scientist., Available from:, http://www.chromatographyonline.com
[5]
Nguyen, D.T.; Guillarme, D.; Rudaz, S.; Veuthey, J.L. Fast analysis in liquid chromatography using small particle size and high pressure. J. Sep. Sci., 2006, 29(12), 1836-1848.
[http://dx.doi.org/10.1002/jssc.200600189] [PMID: 16970187]
[6]
Swartz, M.E. Ultra performance liquid chromatography (UPLC): An introduction, separation science re-defined. LCGC Suppl, 2005, 8, 8-14.
[7]
Jerkovich, A.D.; Mellors, J.S.; Jorgenson, J.W. Uplc: An sensitive and high throughput analysis over HPLC. LC GC, 2003, 21(7), 600-610.
[8]
MacNair, J.E.; Lewis, K.C.; Jorgenson, J.W. Ultrahigh-pressure reversed-phase liquid chromatography in packed capillary columns. Anal. Chem., 1997, 69(6), 983-989.
[http://dx.doi.org/10.1021/ac961094r] [PMID: 9075400]
[9]
Wu, N.; Lippert, J.A.; Lee, M.L. Practical aspects of ultrahigh pressure capillary liquid chromatography. J. Chromatogr. A, 2001, 911(1), 1-12.
[http://dx.doi.org/10.1016/S0021-9673(00)01188-2] [PMID: 11269586]
[10]
Pidgeon, C. Advanced Tutorials for the Biomedical Sciences; Wiley-VCH: Canada, 1996, pp. 119-125.
[11]
Dong, M.W. Modern HPLC for Practicing Scientists; Wiley Interscience: New Jersey, 2006, pp. 35-37.
[http://dx.doi.org/10.1002/0471973106]
[12]
Swartz, M.E. Ultra performance liquid chromatography: Tomorrow’s HPLC technology today. Lab Plus Int., 2004, 18, 6-9.
[13]
Cheng, Y-F.; Walter, T.H.; Lu, Z.; Iraneta, P.; Gendreau, C.; Neue, U.D.; Grassi, J.M.; Carmody, J.L.; O’Gara, J.E.; Fisk, R.P. hybrid organic-inorganic particle technology: breaking through traditional barriers of separations. LC GC, 2000, 18, 1162-1173.
[14]
Neue, U.D.; Walter, T.H.; Alden, B.A. Jiang, Z.; Fisk, R.P.; Cook, J.T.; Glose, K.H.; Carmody, J.L.; Grassi, J.M.; Cheng, Y. Lu, Z. Use of high-performance LC packings from pH 1 to pH 12. Am. Lab., 1999, 31, 36-39.
[15]
Halász, I.; Endele, R.; Asshauer, J. Ultimate limits in high-pressure liquid chromatography. J. Chromatogr. A, 1975, 112, 37-60.
[http://dx.doi.org/10.1016/S0021-9673(00)99941-2]
[16]
Nováková, L.; Matysová, L.; Solich, P. Advantages of application of UPLC in pharmaceutical analysis. Talanta, 2006, 68(3), 908-918.
[http://dx.doi.org/10.1016/j.talanta.2005.06.035] [PMID: 18970409]
[17]
MacNair, J.E.; Patel, K.D.; Jorgenson, J.W. Ultrahigh-pressure reversed-phase capillary liquid chromatography: isocratic and gradient elution using columns packed with 1.0-micron particles. Anal. Chem., 1999, 71(3), 700-708.
[http://dx.doi.org/10.1021/ac9807013] [PMID: 9989386]
[18]
Jorgenson, J.W.; Lukacs, K.D. Free-zone electrophoresis in glass capillaries. Clin. Chem., 1981, 27(9), 1551-1553.
[PMID: 7261333]
[19]
MacNair, J.E.; Lewis, K.C.; Jorgenson, J.W. Ultrahigh-pressure reversed-phase liquid chromatography in packed capillary columns. Anal. Chem., 1997, 69(6), 983-989.
[http://dx.doi.org/10.1021/ac961094r] [PMID: 9075400]
[20]
Prathap, G.M.; Nishat, A. Ultra performance liquid chromatography: A chromatography technique. Int. J. Pharm., 2013, 3(1), 251-260.
[PMID: 23916726]
[21]
Colón, L.A.; Cintrón, J.M.; Anspach, J.A.; Fermier, A.M.; Swinney, K.A. Very high pressure HPLC with 1 mm id columns. Analyst (Lond.), 2004, 129(6), 503-504.
[http://dx.doi.org/10.1039/B405242K] [PMID: 15152325]
[22]
Ynddal, L.; Hansen, S.H. On-line turbulent-flow chromatography-high-performance liquid chromatography-mass spectrometry for fast sample preparation and quantitation. J. Chromatogr. A, 2003, 1020(1), 59-67.
[http://dx.doi.org/10.1016/S0021-9673(03)00773-8] [PMID: 14661757]
[23]
McLoughlin, D.A.; Olah, T.V.; Gilbert, J.D. A direct technique for the simultaneous determination of 10 drug candidates in plasma by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry interfaced to a Prospekt solid-phase extraction system. J. Pharm. Biomed. Anal., 1997, 15(12), 1893-1901.
[http://dx.doi.org/10.1016/S0731-7085(96)02011-0] [PMID: 9278895]
[24]
Wu, N.; Collins, D.C.; Lippert, J.A.; Xiang, Y.; Lee, M.L. Ultrahigh pressure liquid chromatography/time-of-flight mass spectrometry for fast separations. J. Microcolumn Sep., 2000, 12(8), 462-469.
[http://dx.doi.org/10.1002/1520-667X(2000)12:8<462:AID-MCS5>3.0.CO;2-F]
[25]
de Villiers, A.; Lestremau, F.; Szucs, R.; Gélébart, S.; David, F.; Sandra, P. Evaluation of ultra performance liquid chromatography. Part I. Possibilities and limitations. J. Chromatogr. A, 2006, 1127(1-2), 60-69.
[http://dx.doi.org/10.1016/j.chroma.2006.05.071] [PMID: 16797562]
[26]
Wu, N.; Clausen, A.M. Fundamental and practical aspects of ultrahigh pressure liquid chromatography for fast separations. J. Sep. Sci., 2007, 30(8), 1167-1182.
[http://dx.doi.org/10.1002/jssc.200700026] [PMID: 17595952]
[27]
Zhang, G.F.; Storozhenko, S.; Van Der Straeten, D.; Lambert, W.E. Investigation of the extraction behavior of the main monoglutamate folates from spinach by liquid chromatography–electrospray ionization tandem mass spectrometry. J of Chrom A., 2005, 1078(1-2), 59-66.
[28]
Acquity UPLC column. Available at:, https://www.waters.com/webassets/cms/library/docs/720001140en.pdf
[29]
Ynddal, L.; Hansen, S.H. On-line turbulent-flow chromatography-high-performance liquid chromatography-mass spectrometry for fast sample preparation and quantitation. J. Chromatogr. A, 2003, 1020(1), 59-67.
[http://dx.doi.org/10.1016/S0021-9673(03)00773-8] [PMID: 14661757]
[30]
McLoughlin, D.A.; Olah, T.V.; Gilbert, J.D. A direct technique for the simultaneous determination of 10 drug candidates in plasma by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry interfaced to a Prospekt solid-phase extraction system. J. Pharm. Biomed. Anal., 1997, 15(12), 1893-1901.
[http://dx.doi.org/10.1016/S0731-7085(96)02011-0] [PMID: 9278895]
[31]
Broske, A.D. Agilent technologies application, note, 2004.https://www.agilent.com/cs/library/primers/Public/5991-3326EN_SPHB.pdf
[32]
De Brouwer, V.; Storozhenko, S.; Stove, C.P.; Van Daele, J.; Van der Straeten, D.; Lambert, W.E. Ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) for the sensitive determination of folates in rice. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2010, 878(3-4), 509-513.
[http://dx.doi.org/10.1016/j.jchromb.2009.12.032] [PMID: 20061193]
[33]
Storozhenko, S.; De Brouwer, V.; Volckaert, M.; Navarrete, O.; Blancquaert, D.; Zhang, G.F.; Lambert, W.; Van Der Straeten, D. Folate fortification of rice by metabolic engineering. Nat. Biotechnol., 2007, 25(11), 1277-1279.
[http://dx.doi.org/10.1038/nbt1351] [PMID: 17934451]
[34]
Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline; National Academies Press: US 1998.
[35]
Spies, T.D.; Cooper, C.; Blankenhorn, M.A. The use of nicotinic acid in the treatment of pellagra. J. Am. Med. Assoc., 1938, 110(9), 622-627.
[http://dx.doi.org/10.1001/jama.1938.02790090004002]
[36]
Hampel, D.; York, E.R.; Allen, L.H. Ultra-performance liquid chromatography tandem mass-spectrometry (UPLC-MS/MS) for the rapid, simultaneous analysis of thiamin, riboflavin, flavin adenine dinucleotide, nicotinamide and pyridoxal in human milk. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2012, 903, 7-13.
[http://dx.doi.org/10.1016/j.jchromb.2012.06.024] [PMID: 22819611]
[37]
Wu, Y.; Xian, Y.; Guo, X.; Chen, L.; Zhao, X.; Wang, B.; Wang, L. Development and validation of a screening and quantification method for simultaneous determination of seven fluorescent whitening agents in commercial flour using UPLC-MS/MS. Food Chem., 2018, 243, 162-167.
[http://dx.doi.org/10.1016/j.foodchem.2017.09.110] [PMID: 29146323]
[38]
Bazzano, L.A.; He, J.; Ogden, L.G.; Loria, C.M.; Vupputuri, S.; Myers, L.; Whelton, P.K. Fruit and vegetable intake and risk of cardiovascular disease in US adults: the first National Health and Nutrition Examination Survey Epidemiologic Follow-up Study. Am. J. Clin. Nutr., 2002, 76(1), 93-99.
[http://dx.doi.org/10.1093/ajcn/76.1.93] [PMID: 12081821]
[39]
Gruz, J.; Novák, O.; Strnad, M. Rapid analysis of phenolic acids in beverages by UPLC–MS/MS. Food Chem., 2008, 111(3), 789-794.
[http://dx.doi.org/10.1016/j.foodchem.2008.05.014]
[40]
Wren, S.A. Peak capacity in gradient ultra performance liquid chromatography (UPLC). J. Pharm. Biomed. Anal., 2005, 38(2), 337-343.
[http://dx.doi.org/10.1016/j.jpba.2004.12.028] [PMID: 15925228]
[41]
Kovalczuk, T.; Jech, M.; Poustka, J.; Hajslová, J. Ultra-performance liquid chromatography-tandem mass spectrometry: a novel challenge in multiresidue pesticide analysis in food. Anal. Chim. Acta, 2006, 577(1), 8-17.
[http://dx.doi.org/10.1016/j.aca.2006.06.023] [PMID: 17723647]
[42]
Snyder, L.R.; Dolan, J.W.; Gant, J.R. Gradient elution in high-performance liquid chromatography: I. Theoretical basis for reversed-phase systems. J Chrom A, 1979, 165(1), 3-30.
[http://dx.doi.org/10.1016/S0021-9673(00)85726-X]
[43]
Klein, J.; Alder, L. Applicability of gradient liquid chromatography with tandem mass spectrometry to the simultaneous screening for about 100 pesticides in crops. J. AOAC Int., 2003, 86(5), 1015-1037.
[PMID: 14632406]
[44]
González-Jartín, J.M.; Alfonso, A.; Rodríguez, I.; Sainz, M.J.; Vieytes, M.R.; Botana, L.M. A QuEChERS based extraction procedure coupled to UPLC-MS/MS detection for mycotoxins analysis in beer. Food Chem., 2019, 275, 703-710.
[http://dx.doi.org/10.1016/j.foodchem.2018.09.162] [PMID: 30724252]
[45]
Clauson-Kaas, F.; Hansen, H.C.B.; Strobel, B.W. UPLC-MS/MS determination of ptaquiloside and pterosin B in preserved natural water. Anal. Bioanal. Chem., 2016, 408(28), 7981-7990.
[http://dx.doi.org/10.1007/s00216-016-9895-z] [PMID: 27590319]
[46]
Clauson-Kaas, F.; Jensen, P.H.; Jacobsen, O.S.; Juhler, R.K.; Hansen, H.C.B. The naturally occurring carcinogen ptaquiloside is present in groundwater below bracken vegetation. Environ. Toxicol. Chem., 2014, 33(5), 1030-1034.
[http://dx.doi.org/10.1002/etc.2533] [PMID: 24464773]
[47]
Cecchi, M.; Capriles, N.; Watson, S.J.; Akil, H. β1 adrenergic receptors in the bed nucleus of stria terminalis mediate differential responses to opiate withdrawal. Neuropsychopharmacology, 2007, 32(3), 589-599.
[http://dx.doi.org/10.1038/sj.npp.1301140] [PMID: 16823388]
[48]
Drummer, O.H. Requirements for bioanalytical procedures in postmortem toxicology. Anal. Bioanal. Chem., 2007, 388(7), 1495-1503.
[http://dx.doi.org/10.1007/s00216-007-1238-7]
[49]
Berg, T.; Lundanes, E.; Christophersen, A.S.; Strand, D.H. Determination of opiates and cocaine in urine by high pH mobile phase reversed phase UPLC-MS/MS. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2009, 877(4), 421-432.
[http://dx.doi.org/10.1016/j.jchromb.2008.12.052] [PMID: 19144579]
[50]
Pharmacopoeia of the People’s Republic of China; , 2005, Vol. 1, .
[51]
Chan, C.O.; Xie, X.J.; Wan, S.W.; Zhou, G.L.; Yuen, A.C.Y.; Mok, D.K.M.; Chen, S.B. Qualitative and quantitative analysis of sesquiterpene lactones inCentipeda minima by UPLC–Orbitrap–MS & UPLC-QQQ-MS. Jpba, 2019, 17, 360-366.
[52]
Tao, Y.; Huang, S.; Yan, J.; Cai, B. Establishment of a rapid and sensitive UPLC-MS/MS method for pharmacokinetic determination of nine alkaloids of crude and processed Corydalis turtschaninovii Besser aqueous extracts in rat plasma. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2019, 1124, 218-225.
[http://dx.doi.org/10.1016/j.jchromb.2019.06.018] [PMID: 31233942]
[53]
Zhang, J.; Fu, Y.; Li, L.; Liu, Y.; Zhang, C.; Yu, D.; Ma, Y.; Xiao, Y. Pharmacokinetic comparisons of major bioactive components after oral administration of raw and steamed rhubarb by UPLC-MS/MS. J. Pharm. Biomed. Anal., 2019, 171, 43-51.
[http://dx.doi.org/10.1016/j.jpba.2019.04.002] [PMID: 30965220]
[54]
Li, L.; Luo, G.A.; Liang, Q.L.; Hu, P.; Wang, Y.M. Rapid qualitative and quantitative analyses of Asian ginseng in adulterated American ginseng preparations by UPLC/Q-TOF-MS. J. Pharm. Biomed. Anal., 2010, 52(1), 66-72.
[55]
Li, L.; Luo, G.A.; Liang, Q.L.; Hu, P.; Wang, Y.M. Rapid qualitative and quantitative analyses of Asian ginseng in adulterated American ginseng preparations by UPLC/Q-TOF-MS. J. Pharm. Biomed. Anal., 2010, 52(1), 66-72.
[56]
Anand, P.; Sundaram, C.; Jhurani, S.; Kunnumakkara, A.B.; Aggarwal, B.B. Curcumin and cancer: an “old-age” disease with an “age-old” solution. Cancer Lett., 2008, 267(1), 133-164.
[http://dx.doi.org/10.1016/j.canlet.2008.03.025] [PMID: 18462866]
[57]
Chattopadhyay, I.; Biswas, K.; Bandyopadhyay, U.; Banerjee, R.K. Turmeric and curcumin: Biological actions and medicinal applications. Curr. Sci. Banglore, 2004, 87, 44-53.
[58]
Hayun, H.; Rahmawati, R.; Harahap, Y.; Sari, S.P. Development of UPLC–MS/MS method for quantitative analysis of curcumin in human plasma. Acta Chromatogr., 2018, 30(4), 207-211.
[http://dx.doi.org/10.1556/1326.2017.00153]
[59]
Bogusz, M.J. Liquid chromatography-mass spectrometry as a routine method in forensic sciences: a proof of maturity. J. Chromatogr. B Biomed. Sci. Appl., 2000, 748(1), 3-19.
[http://dx.doi.org/10.1016/S0378-4347(00)00461-8] [PMID: 11092582]
[60]
Apollonio, Luigino,. G.; Ian, R.; Whittall, Dennis J.; Pianca, Jennelle, M.; Kyd., William, A. M. Matrix effect and cross-reactivity of select amphetamine-type substances, designer analogues, and putrefactive amines using the Bio-Quant direct ELISA presumptive assays for amphetamine and methamphetamine. J. Anal. Toxicol., 2007, 31(4), 208-213.
[61]
Apollonio, L.G.; Pianca, D.J.; Whittall, I.R.; Maher, W.A.; Kyd, J.M. A demonstration of the use of ultra-performance liquid chromatography–mass spectrometry [UPLC/MS] in the determination of amphetamine-type substances and ketamine for forensic and toxicological analysis. J. Chrom B., 2006, 836(1-2), 111-115.
[62]
Gadgil, P.; Ibrahim, F.; Chow, D.L. UPLC–MS/MS assay of 21-aminosteroid (lazaroid U74389G) for application in pharmacokinetic study. J. Pharm. Biomed. Anal., 2016, 122, 90-97.
[63]
Hall, E.D. Neuroprotective actions of glucocorticoid and nonglucocorticoid steroids in acute neuronal injury. Cell. Mol. Neurobiol., 1993, 13(4), 415-432.
[http://dx.doi.org/10.1007/BF00711581] [PMID: 8252611]
[64]
Kavanagh, R.J.; Kam, P.C.A. Lazaroids: efficacy and mechanism of action of the 21-aminosteroids in neuroprotection. Br. J. Anaesth., 2001, 86(1), 110-119.
[http://dx.doi.org/10.1093/bja/86.1.110] [PMID: 11575384]
[65]
Laizure, S.C.; Franklin, L.K.; Kaiser, D.G.; Williams, C.L.; Stevens, R.C.; Sanders, P.L.; Miller, M. Disposition of tirilazad (U74006F), a 21-aminosteroid, in the plasma, heart, brain, and liver of the rat. Drug Metab. Dispos., 1993, 21(5), 951-954.
[PMID: 7902261]
[66]
Shinde, V.P.; Pudage, A.; Jangid, A.; Mistri, H.; Patel, P.K. Application of UPLC–MS/MS for separation and quantification of 3α-Hydroxy Tibolone and comparative bioavailability of two Tibolone formulations in healthy volunteers. J. Pharm. Anal., 2013, 3(4), 270-277.
[67]
Albertazzi, P.; Di Micco, R.; Zanardi, E. Tibolone: a review. Maturitas, 1998, 30(3), 295-305.
[http://dx.doi.org/10.1016/S0378-5122(98)00059-0] [PMID: 9881330]
[68]
Matuszewski, B.K.; Constanzer, M.L.; Chavez-Eng, C.M. Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. Anal. Chem., 2003, 75(13), 3019-3030.
[http://dx.doi.org/10.1021/ac020361s] [PMID: 12964746]
[69]
Cornely, O.A.; Maertens, J.; Winston, D.J.; Perfect, J.; Ullmann, A.J.; Walsh, T.J.; Helfgott, D.; Holowiecki, J.; Stockelberg, D.; Goh, Y.T.; Petrini, M.; Hardalo, C.; Suresh, R.; Angulo-Gonzalez, D. Posaconazole vs. fluconazole or itraconazole prophylaxis in patients with neutropenia. N. Engl. J. Med., 2007, 356(4), 348-359.
[http://dx.doi.org/10.1056/NEJMoa061094] [PMID: 17251531]
[70]
Müller, C.; Arndt, M.; Queckenberg, C.; Cornely, O.A.; Theisohn, M. HPLC analysis of the antifungal agent posaconazole in patients with haematological diseases. Mycoses, 2006, 49(Suppl. 1), 17-22.
[http://dx.doi.org/10.1111/j.1439-0507.2006.01297.x] [PMID: 16961577]
[71]
Rochat, B.; Pascual, A.; Pesse, B.; Lamoth, F.; Sanglard, D.; Decosterd, L.A.; Bille, J.; Marchetti, O. Ultra-performance liquid chromatography mass spectrometry and sensitive bioassay methods for quantification of posaconazole plasma concentrations after oral dosing. Antimicrob. Agents Chemother., 2010, 54(12), 5074-5081.
[http://dx.doi.org/10.1128/AAC.00022-10] [PMID: 20921320]
[72]
Corda, D.; Iurisci, C.; Berrie, C.P. Biological activities and metabolism of the lysophosphoinositides and glycerophosphoinositols. Biochim. Biophys. Acta, 2002, 1582(1-3), 52-69.
[http://dx.doi.org/10.1016/S1388-1981(02)00137-3] [PMID: 12069810]
[73]
Grauso, L.; Mariggiò, S.; Corda, D.; Fontana, A.; Cutignano, A. An improved UPLC-MS/MS platform for quantitative analysis of glycerophosphoinositol in mammalian cells. PLoS One, 2015, 10(4)e0123198
[http://dx.doi.org/10.1371/journal.pone.0123198] [PMID: 25860666]
[74]
Mariggiò, S.; Sebastià, J.; Filippi, B.M.; Iurisci, C.; Volonté, C.; Amadio, S.; De Falco, V.; Santoro, M.; Corda, D.; Mariggiò, S.; Sebastià, J. A novel pathway of cell growth regulation mediated by a PLA2α-derived phosphoinositide metabolite. FASEB J., 2006, 20(14), 2567-2569.
[http://dx.doi.org/10.1096/fj.05-5397fje] [PMID: 17060404]
[75]
Mariggiò, S.; Filippi, B.M.; Iurisci, C.; Dragani, L.K.; De Falco, V.; Santoro, M.; Corda, D. Cytosolic phospholipase A2 α regulates cell growth in RET/PTC-transformed thyroid cells. Cancer Res., 2007, 67(24), 11769-11778.
[http://dx.doi.org/10.1158/0008-5472.CAN-07-1997] [PMID: 18089807]
[76]
Zhuang, Q.; Liu, X.; Sun, Z.; Wang, H.; Jiang, J. A validated UPLC-MS/MS method to determine free and total irinotecan and its two metabolites in human plasma after intravenous administration of irinotecan hydrochloride liposome injection. J. Pharm. Biomed. Anal., 2019, 170, 112-123.
[http://dx.doi.org/10.1016/j.jpba.2019.03.034] [PMID: 30921645]
[77]
Xu, R.A.; Lin, Q.; Qiu, X.; Chen, J.; Shao, Y.; Hu, G.; Lin, G. UPLC-MS/MS method for the simultaneous determination of imatinib, voriconazole and their metabolites concentrations in rat plasma. J. Pharm. Biomed. Anal., 2019, 166, 6-12.
[http://dx.doi.org/10.1016/j.jpba.2018.12.036] [PMID: 30594035]
[78]
van Seyen, M.; de Graaff Teulen, M.J.A.; van Erp, N.P.; Burger, D.M. Quantification of second generation direct-acting antivirals daclatasvir, elbasvir, grazoprevir, ledipasvir, simeprevir, sofosbuvir and velpatasvir in human plasma by UPLC-MS/MS. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2019, 1110-1111, 15-24.
[http://dx.doi.org/10.1016/j.jchromb.2019.01.024] [PMID: 30776611]
[79]
Qiu, X.; Xie, S.; Ye, L.; Xu, R.A. UPLC-MS/MS method for the quantification of ertugliflozin and sitagliptin in rat plasma. Anal. Biochem., 2019, 567, 112-116.
[http://dx.doi.org/10.1016/j.ab.2018.12.016] [PMID: 30578763]
[80]
Lin, Q.M.; Pang, N.H.; Li, Y.H.; Huang, H.L.; Zhang, X.D.; Hu, G.X.; Wang, Z.S. Investigation of the effects of axitinib on the pharmacokinetics of loperamide and its main metabolite N-demethylated loperamide in rats by UPLC-MS/MS. Chem. Biol. Interact., 2019.310108744
[http://dx.doi.org/10.1016/j.cbi.2019.108744] [PMID: 31299239]
[81]
Lin, C.N.; Wu, I.W.; Huang, Y.F.; Peng, S.Y.; Huang, Y.C.; Ning, H.C. Measuring serum total and free indoxyl sulfate and p-cresyl sulfate in chronic kidney disease using UPLC-MS/MS. Yao Wu Shi Pin Fen Xi, 2019, 27(2), 502-509.
[http://dx.doi.org/10.1016/j.jfda.2018.10.008] [PMID: 30987721]
[82]
Deng, G.; Liu, W.; Ma, C.; Rong, X.; Zhang, Y.; Wang, Y.; Wu, C.; Cao, N.; Ding, W.; Guan, H.; Cheng, X.; Wang, C. In vivo and in vitro metabolism and pharmacokinetics of cholinesterase inhibitor deoxyvasicine from aerial parts of Peganum harmala Linn in rats via UPLC-ESI-QTOF-MS and UPLC-ESI-MS/MS. J. Ethnopharmacol., 2019, 236, 288-301.
[http://dx.doi.org/10.1016/j.jep.2019.03.020] [PMID: 30872168]

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